Data provided by Applied Health
side effects, nutrient depletions, herbal interactions and health notes:
• This drug may cause changes in appetite and weight. It also increases thirst.1
• Alcohol should be avoided while taking Zyprexa, as it may reduce the effectiveness of the drug. The use of alcohol may also slow down the nervous system and cause low blood pressure. Symptoms of slurred speech, loss of balance, confusion, dizziness and decreased mental acuity may also occur when alcohol is being used during drug treatment.2
• Phenylalanine may exacerbate tardive dyskinesia when used in schizophrenia patients.3
• Glycine may support the effectiveness of Zyprexa, as individuals with schizophrenia found their symptoms decreased when glycine was added to their treatment of Zyprexa4
• Smoking increases drug clearance by 40%.5
• The sedative properties of the following herbs may increase CNS side effects of Zyprexa: calamus, calendula, chamomile, California poppy, catnip, couch grass, elecampane, ginseng Siberian, goldenseal, gotu kola, hops, Jamaican dogwood, kava, lemon balm, sage, St. John's wort, sassafras, scullcap, shepherd's purse, stinging nettle, valerian, withania root, and yerba mansa6
References1 Pronsky, Z Food Medication Interactions, 11th edition, 1999
2 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
2 Pronsky, Z Food Medication Interactions, 11th edition, 1999
2 Ereshefsky L. Pharmacologic and pharmacokinetic considerations in choosing an antipsychotic. J Clin Psychiatry 1999;60(Suppl 10):20-30.
2 Threlkeld DS, ed. Central Nervous System Drugs, Antipsychotic Agents. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparison, 1999, 1693.
3 Mosnik DM, Spring B, Rogers K, and Baruah SL. Tardive dyskinesia exacerbated after ingestion of phenylalanine by schizophrenic patients. Neuropsychopharmacology 16(2): 136-146, 1997.
4 Heresco-Levy U, Ermilov M, Lichtenberg P, et al. High-dose glycine added to olanzapine and risperidone for the treatment of schizophrenia. Biol Psychiatry 2004;55:165-71
5 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
5 Pronsky, Z Food Medication Interactions, 11th edition, 1999
6 Brinker F. Herb contraindications and drug interactions, 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998
6 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996
6 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
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The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.