Data provided by Applied Health
side effects, nutrient depletions, herbal interactions and health notes:
• Avoid alcohol with this medication.1
• Vitamins B1, B2 and B6 as well as Co-Q-10 may become deficient with long term use of tricyclic antidepressants.2
• The following herbs may have sedative qualities and could intensify the effects of Amitriptyline: Calendula, Chamomile, Hops, Kava kava, Nettle, Passion Flower, Skullcap, Shepherd’s Purse, St. John’s Wort, Valerian, Wild Carrot Seed and Wild Lettuce.3
• Avoid Panax ginseng with antidepressants like amitriptyline due to the possibility of it triggering manic episodes.4
• Avoid combining yohimbine with tricyclic antidepressants because it could cause an increase in blood pressure.5
• Avoid St. John's Wort with antidepressants, it may have additive effects or increase side effects of the drugs.6
References1 Hudson CJ: Tricyclic antidepressants and alcoholic blackouts. J Nerv Ment Dis 1981; 169:381.
1 Marco LA & Randels RM: Drug interactions in alcoholic patients. Hillside J Clin Psychiatry 1981; 3:27-44.
1 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
1 Pronsky, Z Food Medication Interactions, 11th edition, 1999
2 Bell IR, Edman JS, Morrow FD, et al: Brief communication - Vitamin B1, B2, and B6 augmentation of tricyclic antidepressant treatment in geriatric depression with cognitive function, J Am Coll Nutr, 1992, 11(2):159-63.
2 Pinto, J.T. & Rivlin, R.S. : Drugs that promote renal excretion of riboflavin. Drug Nutrient Interactions, 1987, 5: 143-151.
2 Tinguely D, Jonzier M, Schopf J, et al: Determination of compliance with riboflavin in an antidepressive therapy, Arzneimittelforschung, 1985, 35(2):536-8.
2 Kishi T, et al: Inhibition of myocardial respiration by psychotherapeutic drugs and prevention by Coenzyme Q10, Biomedical and Clinical Aspects of Coenzyme Q10, 1980, 2:139-54.
2 Edelbroek PM, Zitman FG, Schreuder JN, et al: Amitriptyline metabolism in relation to antidepressive effect, Clin Pharmacol Ther, 1984, 35(4):467-73.
3 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.
3 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
3 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
4 Fugh-Berman A. Herb-drug interactions. Lancet. 2000 Jan 8;355(9198):134-8. Review.
5 Fugh-Berman A. Herb-drug interactions. Lancet. 2000 Jan 8;355(9198):134-8. Review.
5 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
6 Cupp MJ. Herbal remedies: adverse effects and drug interactions. Am Fam Physician. 1999 Mar 1;59(5):1239-45. Review.
6 Lantz MS, Buchalter E, Giambanco V. St. John's wort and antidepressant drug interactions in the elderly. J Geriatr Psychiatry Neurol. 1999 Spring;12(1):7-10.
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The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.