Data provided by Applied Health
side effects, nutrient depletions, herbal interactions and health notes:
• Aspirin increases urinary excretion of vitamin C. Decreased vitamin status with respect to vitamin C as well as folate have been noted.1
• Take with food or milk to decrease stomach upset2
• Avoid alcohol.3
• May cause glucose level changes, caution with diabetes4
• Taking vitamin E together with aspirin has been associated with bleeding problems.5
• The use of over three grams of aspirin has been associated with zinc depletion.6
• The antithrombotic effect of garlic plant, ginger, ginkgo or onion plant may be increased by concomitant administration of salicylates like aspirin.7
• Licorice root reduces aspirin absorption and protects gastric mucosa against aspirin toxicity8
• Due to presence of salicylates in meadowsweet, poplar and white willow, it may potentiate the effects of other anticoagulant agents, such as aspirin, and heparin.9
References1 Pronsky, Z Food Medication Interactions, 11th edition, 1999.
1 McKevoy GK, ed. AHFS Drug Information. Bethesda MD: American Society of Health-System Pharmacists, 1998
1 Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
1 Coffey G, Wilson CWM. Ascorbic acid deficiency and aspirin induced haematemesis. BMJ 1975; I: 208.
1 Buist RA. Drug-nutrient interactions: an overview. Intl Clin Nutr Rev 1984;4(3):114 .
2 Pronsky, Z Food Medication Interactions, 11th edition, 1999
3 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
3 Pronsky, Z Food Medication Interactions, 11th edition, 1999
4 Pronsky, Z Food Medication Interacations, 11th edition, 1999
5 Liede KE, Haukka JK, Saxén LM, Heinon OP. Increased tendency towards gingival bleeding caused by joint effect of alpha-tocopherol supplementation and acetylsalicylic acid. Ann Med 1998;30:542-46.
6 Ambanelli U, Ferraccioli GF, Serventi G, Vaona GL. Changes in serum and urinary zinc induced by ASA and indomethacin. Scand J Rheumatol 1982;11:63-64
7 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996
7 Pronsky, Z Food Medication Interactions, 11th editon, 1999
7 Rosenblatt M, Mindel . Spontaneous hyphema associated with ingestion of Ginkgo biloba extract. J N Eng J Med 1997; 336: (15):1108
7 Rowin J, Lewis SL. Spontaneous bilateral subdural hematomas associated with chronic Ginkgo biloba ingestion. Neurology 1996;46:1775-6.
8 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
8 Rees WDW, Rhodes J, Wright JE, et al. Effect of deglycyrrhizinated liquorice on gastric mucosal damage by aspirin. Scand J Gastroenterol 1979;14:605-7.
9 Facts and Comparisons, Review of Natural Products, Wolters Kluwer Company, 2000.
9 Janssen PL: Acetylsalicylate and salicylates in foods. Cancer Lett, 1997 Mar, 114:1-2, 163-4.
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The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.