Data provided by Applied Health
side effects, nutrient depletions, herbal interactions and health notes:
• Use of alcohol should be avoided.1
• Long term use of NSAID's like ibuprofen can cause damage to the gastrointestinal tract leading to iron loss. Consult your physician or pharmacist if you have signs or symptoms of gastrointestinal damage.2
• Ibuprofen may also hinder absorption of folic acid . Supplementation may be beneficial.3
• Consult a pharmacist or physician regarding use of vitamin E supplements with ibuprofen. There is an increased risk of bleeding associated with vitamin E.4
• Licorice might protect the stomach against NSAID damage.5
• Avoid ginkgo with NSAID's, it may increase the risk of bleeding.6
• These herbs have salicylate properties and may have additive effects or side effects with the NSAIDís: meadowsweet, poplar, and white willow.7
References1 Holt GA. Food & Drug Interactions. Chicago, Precept Press, 1998, 137-38.
1 Pronsky, Z Food Medication Interactions, 11th edition, 1999
2 Roe DA: Drug-Induced Nutritional Deficiencies. 2nd ed. Westport, Conn: AVI Publ Co; 1985.
2 Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 139-40.
2 Bjarnason I, Macpherson AJ. Intestinal toxicity of non-steroidal anti-inflammatory drugs. Pharmacol Ther 1994;62:145-57.
3 Roe DA: Drug-Induced Nutritional Deficiencies. 2nd ed. Westport, Conn: AVI Publ Co; 1985.
3 Hodges R. Nutrition in Medical Practice. Philadelphia: W. B. Saunders, 1980, 323-31 [review].
3 Baggott JE, Morgan SL, Ha T, et al: Inhibition of folate-dependent enzymes by nonsteroidal anti-inflammatory drugs, Biochem J, 1992, 282(pt 1):197-202.
3 Shils M, et al. (eds.). Modern nutrition in health and disease, 9th ed. Baltimore: Williams and Wilkins, 1999: 1634.
4 Liede KE, Haukka JK, Saxen LM, et al. Increased tendency toward gingival bleeding caused by joint effect of alpha-tocopherol supplementation and acetylsalicylic acid. Ann Med 30: 542-546, 1998.
5 Rees WDW, Rhodes J, Wright JE, et al, Effect of deglycyrrhizinated liquorice on Gastric Mucosal Damage by Aspirin. Scand J Gastroenterol. 14:605-607, 1979
5 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
6 Rosenblatt, M and Mindel J. Spontaneous Hyphema Associated with Ingestion of Ginkgo biloba Extract N Engl J Med 336(15):1108. 1997
6 Vale S. Subarachnoid haemorrhage associated with Ginkgo biloba. Lancet. 1998 Jul 4;352(9121):36.
6 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
7 Blumenthal, M (Ed.): The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. American Botanical Council. Austin, TX. 1998
7 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
7 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996
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The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.