Data provided by Applied Health
side effects, nutrient depletions, herbal interactions and health notes:
• It is preferable to take this medication separated from food by at least one hour. However, if stomach upset ocurrs, the medication may be taken with food.1
• Avoid caffeine with this medication.2
• Grape juice can speed the elimination of drugs metabolized by the CYP1A2 pathway, like Cognex. Avoid using these agents together, dosage adjustments may need to be made.3
• Huperzine A, also known as Chinese club moss, may interact with Cognex due to its acetylcholinesterase inhibitor properties. Avoid combining both due to possible additive effects or increased side effects.4
• Avoid using ginkgo with Cognex due to possible additive drug effects or increased side effects.5
• Avoid tobacco with Cognex. Nicotine can increase the drug's metabolism.6
• Cognex should not be taken in conjunction with Ipriflavone or hops due to possible risk of increased drug effects. Both seem to inhibit CYP1A2, thereby reducing drug elimination.7
References1 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
2 Zucchero Frederic J., Hogan Mark J., Schultz Christine D. Evaluations of Drug Interactions, 3rd edition, APhA, 1999
3 Xiao Dong S, Zhi Ping Z, Zhong Xiao W, et al. Possible enhancement of the first-pass metabolism of phenacetin by ingestion of grape juice in Chinese subjects. Br J Clin Pharmacol 1999;48(4):638-40.
4 Cheng DH, Tang XC Comparative studies of huperzine A, E2020, and tacrine on behavior and cholinesterase activities. Pharmacol Biochem Behav. 1998 Jun;60(2):377-86.
4 Cheng DH, Ren H, Tang XC Huperzine A, a novel promising acetylcholinesterase inhibitor. Neuroreport. 1996 Dec 20;8(1):97-101.
5 Itil TM, Eralp E, Ahmed I, Kunitz A, Itil KZ The pharmacological effects of ginkgo biloba, a plant extract, on the brain of dementia patients in comparison with tacrine. Psychopharmacol Bull. 1998;34(3):391-7.
5 Wettstein A Cholinesterase inhibitors and Gingko extracts--are they comparable in the treatment of dementia? Comparison of published placebo-controlled efficacy studies of at least six months' duration. Phytomedicine. 2000 Jan;6(6):393-401.
6 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
6 Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
6 Dong SX, Ping ZZ, Xiao WZ, Shu CC, Bartoli A, Gatti G, D'Urso S, Perucca E. Effect of active and passive cigarette smoking on CYP1A2-mediated phenacetin disposition in Chinese subjects. Ther Drug Monit. 1998 Aug;20(4):371-5.
7 Monostory K, Vereczkey L. The effect of ipriflavone and its main metabolites on theophylline biotransformation. Eur J Drug Metab Pharmacokinet. 1996 Jan-Mar;21(1):61-6.
7 Monostory K, Vereczkey L, Levai F, Szatmari I. Ipriflavone as an inhibitor of human cytochrome P450 enzymes. Br J Pharmacol. 1998 Feb;123(4):605-10.
7 Henderson MC, Miranda CL, Stevens JF, Deinzer ML, Buhler DR. In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops, Humulus lupulus. Xenobiotica. 2000 Mar;30(3):235-51.
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The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.