Data provided by Applied Health
side effects, nutrient depletions, herbal interactions and health notes:
• Zantac may increase the risk for deficiencies in calcium, iron, zinc, folic acid and vitamin B12. Discuss a supplementation plan with your physician, with long term use of the medication.1
• Alcohol and tobacco use should be avoided.2
• Limit intake of caffeine, including chocolate, coffee, tea, and sodas. Avoid supplements that contain caffeine.3
• Avoid black tea, coffee, cola nut, cocoa, green tea, guarana and mate with zantac due to their caffeine content.4
• Licorice may theoretically provide an added protective effect with H2 antagonists.5
• Acacia, Black mustard, Capsicum, Devil's Claw, Goldenseal,and Horseradish, all increase gastric acid and could therefore theoretically interact with zantac.6
References1 Aymard JP, Aymard B, Netter P, et al. Haematological adverse effects of histamine H2-receptor antagonists. Med Toxicol Adverse Drug Exp 1988;3:430-48.
1 Hakanson R, Persson P, Axelson J: Elevated serum gastrin after food intake or acid blockade evokes hypocalcemia, Regul Pept, 1990, 28(2):131-6.
1 Skikne BS, Lynch SR, Cook JD: Role of gastric acid in food iron absorption, Gastroenterology, 1981, 81(6):1068-71.
1 Sturniolo GC, Montino MC, Rossetto L, et al: Inhibition of gastric acid secretion reduces zinc absorption in man, J Am Coll Nutr, 1991, 10(4):372-5.
1 Belaiche J, Zittoun J, Marquet J, et al. Effect of ranitidine on secretion of gastric intrinsic factor and absorption of vitamin B12. Gastroenerol Clin Biol, 1983;7(4):381-384.
1 McKevoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
1 Russell WL, Lopez LM, Normann SA et al: Effect of antacids on predicted steady-state cimetidine concentrations. Dig Dis Sci 1984; 29:385-389.
1 Russell RM, Golner BB, Krasinski SD, et al: Effect of antacid and H2 receptor antagonists on the intestinal absorption of folic acid, J Lab Clin Med, 1988, 112(4):458-63.
2 Pronsky, ZM: Food-Medication Interactions, 11th edition, 1999
2 Lieber, CS: Mechanisms of ethanol-drug-nutrition interactions. J Toxicol Clin Toxicol 1994;32(6):631-81.
2 Schurer-Maly CC, Varga L, Koelze HR, Halter F. Smoking and pH response to H2-receptor antagonists. Scand J Gastroenterol 1989;24:1172-78.
3 Pronsky, ZM: Food-Medication Interactions, 11th edition, 1999
4 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
5 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
6 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
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The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.