Data provided by Applied Health
side effects, nutrient depletions, herbal interactions and health notes:
• The binding of the drug to nutrients causes malabsorption1
• Clofibrate impairs absorption of vitamin B122
• Individuals taking clofibrate should avoid supplementing iron, or using multi-vitamin/mineral formulations containing iron, without consulting the prescribing physician, a healthcare professional trained in nutrition, and/or a pharmacist.3
• nutrients affected by drug: Carotene4
References1 Powanda MC, et al. Biochem Pharmacol 1978 Jan 1;27(1):125-127
2 Robinson C, Weigly E. 1984, 46-54
3 Knodel LC, Talbert RL. Adverse effects of hypolipidaemic drugs. Med Toxicol 1987 Jan;2(1):10-32.
3 Powanda MC, Blackburn BS, Bostian KA, Fowler JP, Hauer EC, Pekarek RS. Clofibrate-induced alterations in zinc, iron and copper metabolism. Biochem Pharmacol 1978 Jan 1;27(1):125-127.
3 Powanda MC, Henriksen EL, Ayala E, Canonico PG. Clofibrate-induced alterations in serum protein patterns. Biochem Pharmacol. 1976 Apr 1;25(7):785-788.
3 Robinson C, Weigly E. Basic Nutrition and Diet Therapy. New York: Macmillan, 1984, 46-54.
3 Roe DA. Essential hyperlipemia with xanthomatosis: effects of cholestyramine and clofibrate. Arch Dermatol 1968 Apr;97(4):436-445.
3 Vitamin E Fact Book. LaGrange, IL: VERIS (Vitamin E Research and Information Service), 1994
4 Powanda MC, et al. Biochem Pharmacol 1978 Jan 1;27(1):125-127
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The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.