Data provided by Applied Health
side effects, nutrient depletions, herbal interactions and health notes:
• Lithium is a mineral that may be present in some supplements and is also used in large amounts to treat mood disorders, such as bipolar disorder. Taking lithium at the same time as phenothiazines may result in drug side effects such as disorientation and unconsciousness.1 Though no studies have investigated whether the small amount of lithium available in supplements might interact with prochlorperazine to cause similar effects, people taking the drug should exercise caution when supplementing with lithium.1
• Alcohol Taking prochlorperazine may increase or prolong the effects of alcohol, such as drowsiness, dizziness, and poor coordination.3 Therefore, people taking prochlorperazine should avoid drinking alcohol, especially when they must stay alert.2
• Many antacid products contain aluminum hydroxide, which reduces the absorption of phenothiazine drugs.4 Though no studies are available that confirm an interaction between prochloroperazine and antacids, people who are using antacids should take them an hour before or two hours after the drug.3
• An animal study found that the effects of chlorpromazine, a drug similar to (perphenazine, prochlorperazine, thioridazine), were enhanced when a bacopa extract was given along with it.2 Until more is known, people taking medications from this family of drugs (called phenothiazines) should not take bacopa.4
References1 1. Burnham TH, ed. Central Nervous System Agents, Antipsychotic Agents. In Drug Facts and Comparisons. St. Louis, MO: Facts and Comparisons, 2001, 945–65.
2 3. Sifton DW, et. Physicians’ Desk Reference. Montvale, NJ: Medical Economics Company, Inc., 2000, 2986–8.
3 4. Burnham TH, ed. Central Nervous System Agents, Antipsychotic Agents. In Drug Facts and Comparisons. St. Louis, MO: Facts and Comparisons, 2001, 945–65
4 2. Ganguly DK, Malhotra CL. Some behavioral effects of an active fraction from Herpestis monniera Linn. (Brahmi). Indian J Med Res 1967;55:473–82.
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The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.