Data provided by Applied Health
side effects, nutrient depletions, herbal interactions and health notes:
• Take during the first part of a meal.1
• Prolonged use of drugs of this class, alpha-glucosidase inhibitors, may decrease blood iron levels, due to decreased absorption of iron.2
• Avoid or limit alcohol use.3
• Vitamin E enhances insulin activity and should, therefore, be avoided while taking oral hypoglycemics such as Glyset.4
• The drug may delay the absorption of complex carbohydrates and dietary lactose and other disaccharides.5
• Do not take this medication with charcoal or digestive enzymes, it may reduce the effect of drugs of this class.6
• Avoid L-carnitine, and chromium with oral hypoglycemic agents because there could be an additive hypoglycemic effect.7
• Potatoes can interfere with blood sugar levels and glyset dosage may require adjustment.8
• The following herbs may potentiate the hypoglycemic effects of this drug: Alfalfa, Aloe, Bilberry, Bitter melon, Burdock, Cornsilk, Dandelion, Eucalyptus, Fenugreek, Garlic, Ginger, Ginseng, Gymnema, Juniper, Nettle, Onion, and Tansy.9
References1 Pronsky, Z Food Medication Interaction, 11th edition, 1999
2 Pronsky, Z Food Medication Interaction, 11th edition, 1999
2 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
3 Pronsky, Z Food Medication Interaction, 11th edition, 1999
4 Paolisso G, D'Amore A, Giugliano D, et al. Pharmacologic doses of vitamin E improve insulin action in healthy subjects and non-insulin-dependent diabetic patients. Am J Clin Nutr 57:650-656, 1993.
4 Paolisso G, D'Amore A, Galzerano D, et al. Daily vitamin E supplements improve metabolic control but not insulin secretion in elderly type II diabetic patients. Diabetes Care 16: 1433-1437, 1993.
5 Pronsky, Z Food Medication Interactions, 11th edition, 1999
6 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
7 Mingrone G. L-carnitine improves glucose disposal in type 2 diabetic patients. J Am Col Nutr 18: 77-82, 1999.
7 Anderson RA. Nutritional factors influencing the glucose/insulin system: chromium. J Am Coll Nutr. 1997 Oct;16(5):404-10.
8 Gannon MC, et al. Diabetes Care 1993;16:874.
8 The Review of Natural Products, Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
9 Brinker F. Herb contraindications and drug interactions, 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998: 36, 71, 75, 77, 82.
9 Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
9 Bever BO and Zahnd GR. Plants with oral hypoglycemic action. Q J Crude Drug Res 17: 139-196, 1979.
9 Khan AK, Akhtar S, and Mahtab H. Treatment of diabetes mellitus with Coccinia indica. BMJ 280: 1044, 1980.
9 Mathew PT and Augusti KT. Hypoglycaemic effects of onion, Allium cepa Linn. on diabetes mellitus- a preliminary report. Indian J Physiol Pharmacol 19: 213-217, 1975.
9 Manickam M, Ramanathan M, Jahromi MA, et al. Antihyperglycemic activity of phenolics from Pterocarpus marsupium. J Nat Prod 60: 609-610, 1997.
9 Stern E. Successful use of Atriplex halimus in the treatment of type 2 diabetic patients: a preliminary study. Zamenhoff Medical Center, Tel Aviv, 1989
9 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
9 Neef H, et al. Inhibitory effects of Galega officinalis on glucose transport across monolayers of human intestinal epithelial cells (Caco-2). Pharm Pharmacol Lett 1996;6(2):86-89.
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The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.