Data provided by Applied Health
side effects, nutrient depletions, herbal interactions and health notes:
• Folate and vitamin C supplementation may be helpful with long term use of the medication.1
• Vitamin E intake with NSAIDs may increase risk of bleeding.2
• Take with food or milk to decrease stomach upset3
• Avoid alcohol.4
• Chondroitin sulfate has some anti-platelet properties; consult a pharmacist prior to using NSAID's and chondroitin together due to the increased potential for bleeding.5
• Ulcers induced by NSAIDs may be minimized by Licorice.6
• Due to its blood-thinning properties, taking Ginkgo with NSAIDs may not be advisable.7
• Anti-inflammatory properties of diclofenac may be increased by Stinging Nettle.8
• Avoid feverfew with NSAID's, the herbs' effect may theoretically be reduced.9
References1 Baggott JE, Morgan SL, Ha T, et al. Inhibition of folate-dependent enzymes by non-steroidal anti-inflammatory drugs. Biochem J 282: 197-202, 1992.
1 Lawrence VA, Loewenstein JE, and Eichner ER. Aspirin and folate binding: in vivo and in vitro studies of serum binding and urinary excretion of endogenous folate. J Lab Clin Med 103: 944-948, 1984.
1 Molloy TP and Wilson CW. Protein-binding of ascorbic acid. Interaction with acetylsalicylic acid. Int J Vitam Nutr Res 50: 387-392, 1980.
1 Das N and Nebioglu S. Vitamin C-aspirin interactions in laboratory animals. J Clin Pharm Ther 17: 343-346, 1992.
2 Liede KE, Haukka JK, Saxen LM, et al. Increased tendency toward gingival bleeding caused by joint effect of alpha-tocopherol supplementation and acetylsalicylic acid. Ann Med 30: 542-546, 1998.
2 Steiner M. Vitamin E, a modifier of platelet function: rationale and use in cardiovascular and cerebrovascular disease. Nutr Rev. 1999 Oct;57(10):306-9.
3 Pronsky, Z Food Medication Interactions, 11th edition, 1999.
3 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
4 Pronsky, Z Food Medication Interactions, 11th edition, 1999.
4 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
5 McKevoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 2000.
5 Griffith, Winter H MD Vitamins, herbs, minerals and supplements- the complete guide. Revised edition. Fisher books, 1998.
6 Rees WDW, Rhodes J, Wright JE, et al. Effect of deglycyrrhizinated liquorice on gastric mucosal damage by aspirin. Scand J Gastroenterol 14: 605-607, 1979.
6 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
6 Morgan AG, McAdam WAF, Pascoo C, Darnborough A. Comparison between cimetidine and Caved-S in the treatment of gastric ulceration and subsequent maintenance therapy. Gut 1982;23: 545-51.
7 Rosenblatt M and Mindel J. Spontaneous hyphema associated with ingestion of Ginkgo biloba extract. N Engl J Med 336(15): 1108, 1997.
8 Chrubasik S, Enderlein W, Bauer R, Grabner W. "Evidence for antirheumatic effectiveness of Herba Urticae dioicae in acute arthritis: A pilot study," Phytomedicine, 4(2): 105-108, 1997.
8 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
9 The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 2000.
9 Miller LG. Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions. Arch Int Med 1998;158(20):2200-11.
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The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.