Data provided by Applied Health
side effects, nutrient depletions, herbal interactions and health notes:
• Avoid caffeine found in black tea, coffee, and colas with this medication due to possible decreased drug absorption.1
• Avoid grape juice with this medication, grape juice may decrease drug levels.2
• Take medication with food to avoid stomach upset.3
• Avoid alcohol with this medication.4
• Coenzyme Q10 may be depleted with long term use of this medication.5
• Vitamin E may be helpful in reducing the incidence of tardive dyskinesia associated with the use of this medication.6
• Avoid tobacco, it may increase metabolism of the drug.7
• Cocoa, cola, guarana and mate all have caffeine and this may interfere with this medication.8
• The CNS depressant tendency of: devil's claw, lemonbalm, ma huang, meadowsweet, mullein, peppermint, pokeroot, European poplar, prickly ash, queen of the meadow and sassafras can potentiate CNS side effects of this drug.9
• Avoid alfalfa with this medication due to the increased risk of photosensitivity with this combination.10
References1 Kulhanek F, et al. Precipitation of Antipsychotic drugs in interaction with coffee or tea. Lancet 1979;2:1130.
1 Holt, G Food and Drug Interactions: Revised and Expanded Edition, Precept Press, 1998
1 Lasswell WL Jr., et al. In vitro interaction of neuroleptics and tricylic antidepressants with coffee, tea, and gallotannic acid. J Pharm Sci 1984; 73:1056-8.
2 Xiao Dong S, Zhi Ping Z, Zhong Xiao W, et al. Possible enhancement of the first-pass metabolism of phenacetin by ingestion of grape juice in Chinese subjects. Br J Clin Pharmacol 1999;48(4):638-40.
3 Pronsky, Z Food Medication Interactions, 11th edition, 1999
4 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
4 Pronsky, Z Food Medication Interactions, 11th edition, 1999
5 Folkers K. Basic chemical research on coenzyme Q10 and integrated clinical research on therapy of diseases. As cited in Lenaz G (ed.). Coenzyme Q. New York: John Wiley and Sons, 1985
5 Kishi T, et al, Inhibition of Myocardial Respiration by Psychotherapeutic Drugs and Prevention by Coenzyme-Q, Biomedical and Clinical Aspects of Coenzyme Q, Yamamura Y, Folkers K, and Ito Y, eds, Elsevier/North Holland Biomedical Press: Amsterdam, 1980, Vol 2, 139-54.
6 Adler LA, et al. Long term treatment effects of vitamin E for tardive dyskinesia. Biol Psychiatry 43: 868-872, 1998
6 Inada T: [Recent research trends in diagnosis, treatment, and prevention of drug-induced extrapyramidal symptoms seen in psychiatric patients.] Nihon Shinkei Seishin Yakurigaku Zasshi, 1996 Oct, 16:5, 181-5.
6 Adler LA, et al. Vitamin E treatment of tardive dyskinesia. Am J Psychiatry 150: 1405-1407, 1993.
7 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
8 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
9 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996
9 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
10 Brown R. Potential interactions of herbal medicines with antipsychotics, antidepressants and hypnotics. European Journal of Herbal Medicine 1997;3:25-8.
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The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.