Data provided by Applied Health
side effects, nutrient depletions, herbal interactions and health notes:
• Lescol may affect the absorption or utilization of coenzyme Q10. Supplementation may prove beneficial.1
• Use of alcohol should be limited.2
• Avoid grapefruit juice with the medication because it could increase drug levels of most "statin" drugs, except Pravastatin.3
• Certain herbs may increase the action of this medication and should be discussed with your pharmacist or physician. These include Artichoke plant, Fenugreek, Garlic plant, and Plantain all of which may lower cholesterol levels.4
References1 Ubbink JB: The role of vitamins in the pathogenesis and treatment of hyperhomocyst(e)inaemia. J Inherit Metab Dis, 1997 Jun, 20:2, 316-25.
1 Ghirlanda, G. et al: Evidence of plasma CoQ10-lowering effect by HMG-CoA reductase inhibitors: a double-blind, placebo-controlled study. J. Clin. Pharm. 1993, 33(3): 226-9.
1 Mortensen SA, Leth A, Agner E, Rohde M. Dose-related decrease of serum coenzyme Q10 during treatment with HMG-CoA reductase inhibitors. Mol Aspects Med 1997;18(suppl):S137-44.
1 De Pinieux G, Chariot P, Ammi-Said M, et al: Lipid lowering drugs and mitochondrial function - effects of HMG-CoA Reductase Inhibitors on serum upiquinone and blood lactate/pyruvate ratio, Br J Pharmacol, 1996, 42(3):333-7.
1 Bargossi Am, Grossi G, Fiorella PL, et al: Exogenous CoQ10 supplementation prevents plasma ubiquinone reduction induced by HMG-CoA reductase inhibitors, Mol Aspects Med, 1994, 15 (suppl): 187-93.
2 Pronsky, ZM, et al: Food-Medication Interactions, 11th edition, 1999
3 Kantola T, Kivisto KT, Neuvonen PJ. Grapefruit juice greatly increases serum concentrations of lovastatin and lovastatin acid. Clin Pharmacol Ther 1998;63:396-402.
3 Lilja JJ, Kivisto KT, Neuvonen PJ. Grapefruit juice increases serum concentrations of atorvastatin and has no effect on pravastatin. Clin Pharmacol Ther 1999; 66:118-27.
3 Pronsky, Z Food Medication Interactions, 11th edition, 1999
4 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.
4 Facts and Comparisons, The Review of Natural Products, Clinisphere 2.0, Wolters Kluwer Company, 2000
4 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
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The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.