Data provided by Applied Health
side effects, nutrient depletions, herbal interactions and health notes:
• High fat meals can affect the absorption of this medication. Take this medication on an empty stomach or with a low fat meal.1
• This medication is a protease inhibitor. Studies conducted with this class of medications and St. John's wort indicate that the herb greatly reduces the blood levels of this medication. Do not take St. John's wort with this medication.2
References1 Sifton DW, ed. Physiciansí Desk Reference. Montvale, NJ: Medical Economics Company, Inc., 2000, 1772-6.
1 Yeh KC, Deutsch PJ, Haddix H, et al. Single-dose pharmacokinetics of indinavir and the effect of food. Antimicrob Agents Chemother 1998;42:332-8.
2 Moore LB, Goodwin B, Jones SA, et al. St. Johnís wort induces hepatic drug metabolism through activation of the pregnane X receptor. Proc Natl Acad Sci USA 2000;97:7500-2.
2 Piscitelli SC, Burstein AH, Chaitt D, et al. Indinavir concentrations and St. Johnís wort. Lancet 2000;355:547-8 [letter].
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The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.