Data provided by Applied Health
side effects, nutrient depletions, herbal interactions and health notes:
• There is some evidence that metformin, a sulfonylurea class drug may cause vitamin B12 deficiency. Amaryl may also have similar effects, monitor blood levels periodically with long term use of this medication.1
• High doses of niacin may increase blood glucose levels, and excessive use of this nutrient should be avoided in diabetes.2
• Alcohol use should be limited as it can interfere with diabetes management.3
• Vitamin E may play a beneficial role in protecting against diabetic complications. However, because it can lower blood sugar levels do not supplement large doses of the vitamin without consulting a pharmacist.4
• Potatoes can interfere with blood sugar levels and Amaryl dosage may require adjustment.5
• The following herbs may lower blood sugar levels: Alfalfa, Aloe vera, Bilberry, Bitter melon, Burdock, Celery, Cornsilk, Eucalyptus, Fenugreek, Garlic, Ginger, Panax Ginseng, Juniper, Marshmallow, Myrrh, Nettle, Onions, Sage and Tansy.6
• Licorice is contraindicated in diabetes.7
References1 Adams JF, Clark JS, Ireland JT, et al: Malabsorption of vitamin B12 and intrinsic factor secretion during biguanide therapy, Diabetologia, 1983, 24(1):16-8.
1 Berger W, Incidence of severe side effects during therapy with sulfonylureas and biguanides, Horm Metab Res Suppl, 1985, 15:111-5.
1 Rieder HP, Berger W, and Fridrich R: Vitamin status in diabetic neuropathy, Z Ernahrungswiss, 1980, 19 (1):1-13.
1 Carpentier JL, Bury J, Luyckx A, et al: Vitamin B12 and folic acid serum levels in diabetics under various therapeutic regimens, Diabete Metab, 1976, 2(4):187-90.
2 McKevoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
2 Schwartz ML. Severe reversible hyperglycemia as a consequence of niacin therapy. Arch Intern Med. 1993 Sep 13;153(17):2050-2.
2 Roe DA. Drug and nutrient interactions in the elderly diabetic. Drug Nutr Interact. 1988;5(4):195-203. Review.
3 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
3 Pronsky, Z Food Medication Interactions, 11th edition, 1999
4 Paolisso G, D'Amore A, Giugliano D, et al. Pharmacologic doses of vitamin E improve insulin action in healthy subjects and non-insulin-dependent diabetic patients. Am J Clin Nutr 57:650-656, 1993
4 Ceriello A, Giugliano D, Quatraro A, Donzella C, Dipalo G, Lefebvre PJ. Vitamin E reduction of protein glycosylation in diabetes. New prospect for prevention of diabetic complications? Diabetes Care. 1991 Jan;14(1):68-72.
4 Tutuncu NB, Bayraktar M, Varli K. Reversal of defective nerve conduction with vitamin E supplementation in type 2 diabetes: a preliminary study. Diabetes Care. 1998 Nov;21(11):1915-8.
5 Gannon MC, et al. Diabetes Care 1993;16:874.
5 The Review of Natural Products, Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
6 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.
6 Brinker F. Herb contraindications and drug interactions, 2nd ed. Eclectic Medical Publications, 1998.
6 Welihinda J, et al. Effect of Momordica charantia on the glucose tolerance in maturity onset diabetes. J Ethnopharmacol 17: 277-282, 1986.
7 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.
7 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
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The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.