Data provided by Applied Health
side effects, nutrient depletions, herbal interactions and health notes:
• Certain antacids, calcium supplements and kaolin should be avoided while taking this drug.1
• Grapefruit juice interferes with the metabolism and clearance of quinidine.2
• Potassium balance affects the activity of quinidine, and thus, levels should be monitored.3
• The following herbs can increase the effects and side effects of antiarrhythmic drugs such as quinidine if used concomitantly: Adonis, Aloe, Belladonna leaf and root, Bitter candytuft, Buckthorn bark/berry, Cascara sagrada bark, Cinchona, Digitalis lanata, English hawthorn, Henbane, Lily-of-the-Valley, Pheasant's eyes, Scopolia, Senna pod and leaf, Squill, Strophanthus, and Wallflower.4
• The following herbs may interact with quinidex due to the known interaction between anticoagulants and quinidine: Angelica, Anise, Arnica, Asafoetida, Bogbean, Boldo, Clove, Danshen, Fenugreek, Feverfew, Garlic, Ginseng (Panax), Horse chestnut, Horse radish, Meadowsweet, Prickly ash, Onion, Papain, Turmeric, Wild carrot, Wild lettuce, and Willow.5
• Anticholinergics increase the pharmacological effects of antiarrhythmics; therefore, consult your physician or pharmacist regarding the use of the following anticholinergic herbs with quinidex: Belladonna, Bittersweet nightshade, European mandrake, and Knotweed herb.6
• Prolonged use of the following herbs: Aloe, Black Hellebore, Buckthorn, Cascara sagrada, Chinese rhubarb, Frangula, Lily-of-the-Valley, Ma-Huang, and Strophanthus can cause arrythmias as a side effect and therefore, should not be used with quinidine.7
• Avoid licorice with quinidine due to the increased potential for increased heart rate and low serum potassium levels.8
References1 Pronsky, Z Food Medication Interactions, 11th edition, 1999.
1 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
1 Allen MD, et al. "Effect of magnesium-aluminum hydroxide and kaolin-pectin on absorption of digoxin from tablets and capsules." J Clin Pharmacol, 1981 Jan; 21(1):26-30.
1 Bowman WC. Textbook of Pharmacology, ed. 2. London: Blackwell Scientific Publications, 1980.
2 Pronsky, Z Food Medication Interactions, 11th edition, 1999.
2 Damkier P, Hansen LL, Brosen K. Effect of diclofenac, disulfiram, itraconazole, grapefruit juice and erythromycin on the pharmacokinetics of quinidine. Br J Clin Pharmacol 1999;48(6):829-838.
2 Ha HR, Chen J, Leuenberger PM, Freiburghaus AU, Follah F. In vitro inhibition of midazolam and quinidine metabolism by flavonoids. Eur J Clin Pharmacol. 1995;48:367-71
2 Min DI, Ku YM, Geraets DR, Lee HC. Effect of grapefruit juice on the pharmacokinetics and pharmacodynamics of quinidine in healthy volunteers. J Clin Pharmacol. 1996;36:469-76
3 Pronsky, Z Food Medication Interactions, 11th edition, 1999.
3 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
4 PDR (Physician's Desk Reference) for Herbal Medicines. Second edition. Medical Economics Company. Montvale, NJ. 2000: 205, 259.
4 Blumenthal M, et al. ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
4 Hardman JG, Limbird LL, eds. Goodman and Gillman's The Pharmacological Basis of Therapeutics, ninth edition, New York: McGraw-Hill, 1996.
5 Fetrow CW, Avila JR. Professional's handbook of complementary and alternative medicines. First ed. Springhouse: Springhouse Corporation, 1999.
5 Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
5 Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
5 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000.
6 Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
6 Blumenthal M, et al. ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
6 McKevoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 2000.
6 Gruenwald J, et. al. PDR for Herbal Medicines. 2nd ed. Montvale, NJ: Medical Economics Company, Inc., 2000.
6 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
7 PDR (Physician's Desk Reference) for Herbal Medicines. Second edition. Medical Economics Company. Montvale, NJ. 2000: 205, 259.
7 Facts and Comparisons, Review of Natural Products, Clinisphere 2.0, Wolters Kluwer Company, 2000
8 Eriksson, JW, Carlberg B, Hillorn V. Life Threatening ventricular tachycardia due to liquorice induced hypokalemia. J Intern Med 1999 Mar; 245(3): 307-310.
8 PDR For Herbal Medicines, 2nd edition, Medical Economics Company, 2000
Want more special reports like this e-mailed to you when they're available? Click here for free e-mail alerts.
Share this Special Report by linking to it
Copy and paste the following HTML code into any web page:
The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.