Data provided by Applied Health
side effects, nutrient depletions, herbal interactions and health notes:
• Avoid or limit alcohol use.1
• Grapefruit and grapefruit juice may increase the effects of calcium channel blockers and possibly cause an excessive lowering of blood pressure.2
• Magnesium and potassium supplements may contribute to lowering of blood pressure when used with this medication. Discuss supplementation with a pharmacist.3
• Avoid natural Licorice products, Ginseng and Ephedra (Ma huang), which may interfere with antihypertensive therapy.4
• Some herbs possess cardiac activity which may interact with Adalat: black hellebore, calamus, cereus, cola, coltsfoot, devil's claw, European mistletoe, fenugreek, fumitory, digitalis leaf, hedge mustard, figwort, lily of the valley roots, motherwort, pleurisy root, squill bulb leaf scales, white horehound, mate, scotch broom flower, shepherd's purse, and wild carrot.5
References1 Mindell, E, Hopkins V: Prescription Alternatives. New Canaan, CT: Keats Publishing, Inc, 1998; p 143.
1 Pronsky, Z Food Medication Interactions, 11th edition, 1999
2 Edgar, B et al: Acute effects of drinking grapefruit juice on the pharmacokinetics and dynamics of Felodipine - and its potential clinical relevance. Eur. J. Clin. Pharm. 1992, 42:313-317.
2 Bailey DG, et al. "Interaction of citrus juices with felodipine and nifedipine." Lancet, 1991; 337: 268-69.
2 Fuhr U. "Drug Interactions with Grapefruit Juice." Drug Safety 1998; (4): 251-272.
3 Rybacki, JJ. The Concise Essential Guide to Prescription Drugs, 1997. HarperCollins.
3 Ono A, Shibaoka M, Yano J, Asai Y, Fujita T. Eating habits and intensity of medication in elderly hypertensive outpatients. Hypertens Res. 2000 May;23(3):195-200.
3 Geleijnse JM, Witteman JC, den Breeijen JH, Hofman A, de Jong PT, Pols HA, Grobbee DE. Dietary electrolyte intake and blood pressure in older subjects: the Rotterdam Study. J Hypertens. 1996 Jun;14(6):737-41.
3 Van Leer EM, Seidell JC, Kromhout D. Dietary calcium, potassium, magnesium and blood pressure in the Netherlands. Int J Epidemiol. 1995 Dec;24(6):1117-23.
4 Farese, RV et al., Licorice-induced hypermineralcorticoidism. NEJM. 1991, 325:1,1223-1,227.
4 Pronsky, Z Food Medication Interactions, 11th edition, 1999
4 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
5 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.
5 Facts and Comparisons, The Review of Natural Products, Clinisphere 2.0, Wolters Kluwer Company, 2000
5 Blumenthal M, et al. ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
5 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
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The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.