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Entocort EC
side effects, nutrient depletions, herbal interactions and health notes:

Data provided by Applied Health

This medication has been clinically proven to impair calcium absorption and bone formation. Therefore, supplementation with calcium and vitamin D is strongly encouraged. Inform your pharmacist or physician if you have osteoporosis.1

Corticosteroids may compromise the immune system and deplete several important nutrients. Supplementation with vitamin C , selenium, magnesium, potassium, vitamin B6 and zinc is considered beneficial with long term use of this medication.2

Ask your doctor about restricting your salt intake or eating potassium-rich foods. With prolonged use of this medication, a high protein diet may be helpful.3

A study found N-acetyl cysteine to be of added benefit in treating certain respiratory illnesses when combined with a corticosteroid.4

Ephedra (Ma huang) may increase the clearance of this medication and decrease its effectiveness.5

Licorice may decrease the clearance of this medication and may possibly intensify the duration of its activity and side effects.6



References

1 Sambrook PN: Calcium and vitamin D therapy in corticosteroid bone loss: what is the evidence? J Rheumatol 1996; 23:963-964.

1 Buckley LM, Leib ES, Cartularo KS, et al. Calcium and vitamin D3 supplementation prevents bone loss in the spine secondary to low-dose corticosteroids in patients with rheumatoid arthritis. A randomized, double-blind, placebo-controlled trial. Ann Intern Med 1996;125:961-68.

1 Lems WF, Van Veen GJ, Gerrits MI, et al: Effect of low-dose prednisone (with calcium and calcitrol supplementation) on calcium and bone metabolism in healthy volunteers, Br J Rheumatol, 1998, 37(1):27-33.

1 Gennari C, Differential effect of glucocorticoids on calcium absorption and bone mass, Br J Rheumatol, 1993, 32 (suppl 2):11-4.

1 Reid IR, Ibbertson HK, Calcium supplements in the prevention of steroid-induced osteoporosis, Am J Clin Nutr, 1986, 44 (2):287-90.

1 Weryha G, Klein M, Guillemin F, et al: Corticosteroids osteoporosis in the adult, Presse Med, 1998, 27(32):1641-6.

1 Hachulla E, Cortet B: Prevention of glucocorticoid-induced osteoporosis, Rev Med Interne, 1998, 19(7): 492-500.

1 Gerster JC, So AK, Burkhardt P: Systemic corticosteroid therapy in rheumatology advantages and risks, Schweiz Rundsch Med Prax, 1998, 87(33):1024-7.

2 AMA Drug Evaluations, 1995 Annual, American Medical Association.

2 Holt GA. Food & Drug Interactions. Chicago: Precept Press, 1998, 83.

2 Trovato A et al. Drug-nutrient interactions. Am Family Phys 1991;44:1651-58 [review].

2 Chesney RW et al. Reduction of serum-1,25-dihydroxyvitamin-D, in children receiving glucocorticoids. Lancet 1978;ii:1123-25.

2 Golberg ED, Eshchenko VA, Bovt VD, et al: The effect of immunosuppressive substances on the zinc content in cells, Biull Eksp Biol Med, 1993, 116(10):412-3.

2 Yunice AA, Czerwinski AW, Lindeman RD: Influence of synthetic corticosteroids on plasma zinc and copper levels in humans, Am J Med Sci, 1981, 282(2):68-74.

2 Fodor L, Ahnefeld FW, Fazekas AT: Studies on the glucocorticoid control of zinc metabolism, Infusionsther Klin Ernahr, 1975, 2(3):210-3.

2 Atkinson SA, Halton JM, Bradley C, et al: Bone and mineral abnormalities in childhood acute lymphoblastic leukemia--influence of disease, drugs, and nutrition, Int J Cancer Suppl, 1998, 11:35-9.

2 Simeckova A, Neradilova M, Reisenauer R: Effect of prednisolone on the rat bone calcium, phosphorus, and magnesium concentration, Physiol Bohemoslov, 1985, 34(2):155-60.

2 Frequin ST, Wevers RA, Braam M, et al: Decreased vitamin B12 and folate levels in cerebrospinal fluid and serum of multiple sclerosis s after high-dose intravenous methylprednisone, J Neurol, 1993, 240(5):305-8.

2 Peretz A, Neve J, Vertongen F, et al: Selenium status in relation to clinical variables and corticosteroid treatment in rheumatoid arthritis, J Rheumatol, 1987, 14(6):1104-7.

2 Dukes MNG: Meyler's Side Effects of Drugs, 12th ed. Elsevier Science Publishers BV, Amsterdam, the Netherlands, 1992.

2 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000

3 Widmer P, Maibach R, Kunzi UP, et al: Diuretic-Related hypokalaemia--the role of diuretics, potassium supplements, glucocorticoids, and beta-2-adrenoceptor agonists--results from the Comprehensive Hospital Drug Monitoring program, Berne (CHDM), Eur J Clin Pharmacol, 1995, 49(1-2): 31-6.

3 Rydacki, JJ. The Concise Essential Guide to Prescription Drugs. HarperCollins, 1997.

3 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000

3 Pronsky, Z Food Medication Interactions, 11th edition, 1999

3 Shenfield GM, Knowles GK, Thomas N, et al: Potassium supplements in patients treated with corticosteroids, Br J Dis chest, 1975, 69:171-6.

4 Behr J, Maier K, Degenkolb B, et al. Antioxidative and clinical effects of high-dose N-acetylcysteine in fibrosing alveolitis. Adjunctive therapy to maintenance immunosuppresion. Am J Respir Crit Care Med 1997;156:1897-901.

5 Jubiz W, Meikle AW. Alterations of glucocorticoid actions by other drugs and disease states. Drugs 1979;18:113-21.

6 Chen MF, Shimada F, Kato H, et al. Effect of glycyrrhizin on the pharmacokinetics of prednisolone following low dosage of prednisolone hemisuccinate. Endocrinol Japan 1990;37:331-41.

6 Tamura Y, Nishikawa T, Yamada K, et al. Effects of glycyrrhetinic acid and its derivatives on delta-4-5-alpha- and 5-beta-reductase in rat liver. Arzneim Forsch 1979;29:647-49.



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Disclaimers

The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.

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