Data provided by Applied Health
side effects, nutrient depletions, herbal interactions and health notes:
• There may be an increased need for riboflavin with long term use of thioridazine.1
• Avoid alcohol2
• Co-Q10 may be depleted with long term use.3
• Vitamin E supplementation has been shown to decrease a side effect, (tardive dyskinesia).4
• Phenylalanine may make tardive dyskinesia worse if used with phenothiazines.5
• Milk thistle may protect the liver against long term phenothiazine induced toxicity.6
• Avoid kava with phenothiazines, it may increase CNS side effects.7
• Yohimbe toxicity increases if used together with phenothiazines.8
References1 Tinguely D, Jonzier M, Schopf J, et al. Determination of Compliance with Riboflavin in an Antidepressive Therapy. Arzneimittelforschung, 1985, 35(2): 536-8
1 Pronsky, Z Food Medication Interactions, 11th edition, 1999
2 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
2 Pronsky, Z Food Medication Interactions, 11th edition, 1999
3 Folkers K. Basic chemical research on coenzyme Q10 and integrated clinical research on therapy of diseases. As cited in Lenaz G (ed.). Coenzyme Q. New York: John Wiley and Sons, 1985.
3 Kishi T, et al, "Inhibition of Myocardial Respiration by Psychotherapeutic Drugs an Prevention by Coenzyme Q" Biomedical and Clinical Aspects of Coenzyme Q, Yamamura Y, Folkers K and Ito Y, eds Elsevier/North-Holland Biomedical Press: Amsterdam, 1980, vol 2, 139-54.
4 Adler LA, et al. Long term treatment effects of vitamin E for tardive dyskinesia. Biol Psychiatry 43: 868-872, 1998.
4 Elkashef AM, Wyatt RJ. Tardive dyskinesia: possible involvement of free radicals and treatment with vitamin E. Schizophr Bull. 1999;25(4):731-40. Review.
4 Dorfman-Etrog P, Hermesh H, Prilipko L, Weizman A, Munitz H. The effect of vitamin E addition to acute neuroleptic treatment on the emergence of extrapyramidal side effects in schizophrenic patients: an open label study. Eur Neuropsychopharmacol. 1999 Dec;9(6):475-7.
4 Boomershine KH, Shelton PS, Boomershine JE. Vitamin E in the treatment of tardive dyskinesia. Ann Pharmacother. 1999 Nov;33(11):1195-202. Review.
5 Mosnik DM, Spring B, Rogers K, and Baruah SL. Tardive dyskinesia exacerbated after ingestion of phenylalanine by schizophrenic patients. Neuropsychopharmacology 16(2): 136-146, 1997
5 Gardos G, Cole JO, Matthews JD, Nierenberg AA, Dugan SJ. The acute effects of a loading dose of phenylalanine in unipolar depressed patients with and without tardive dyskinesia. Neuropsychopharmacology. 1992 Jun;6(4):241-7.
6 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
6 Palasciano G, et al. The effect of silymarin on plasma levels of malondialdehyde in patients receiving long term treatment with psychotropic drugs. Curr Ther Res 55: 537-545, 1994.
7 Schelosky L, et al. Kava and dopamine antagonism. J Neurol Neurosurg Psych 58(5): 639-640, 1995.
8 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
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The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.