Data provided by Applied Health
side effects, nutrient depletions, herbal interactions and health notes:
• Take with food for stomach upset.1
• Avoid caffeine with this medication.2
• Take magnesium supplements or antacids separated by at least 2 hours from the drug.3
• Vitamin E may be helpful in reducing the incidence of tardive dyskinesia associated with the use of this medication.4
• Avoid alcohol with this medication.5
• Avoid phenylalanine supplements while taking this medication because the risk of tardive dyskinesia may increase.6
• Avoid tobacco, it may increase metabolism of the drug.7
• Evening Primrose Oil may increase seizure potential if used together with this medication.8
• Avoid cola nut, cocoa, guarana and mate with this medication due to their caffeine content.9
• Kava may increase dystonia if used together with this drug.10
• The CNS depressant tendency of: devil's claw, lemonbalm, ma huang, meadowsweet, mullein, peppermint, pokeroot, European poplar, prickly ash, queen of the meadow and sassafras may potentiate CNS side effects of this medication.11
• Avoid alfalfa with this medication due to the increased risk of photosensitivity.12
References1 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
1 Pronsky, Z Food Medication Interactions, 11th edition, 1999
2 Kulhanek F, et al. Precipitation of Antipsychotic drugs in interaction with coffee or tea. Lancet 1979;2:1130.
2 Lasswell WL Jr., et al. In vitro interaction of neuroleptics and tricylic antidepressants with coffee, tea, and gallotannic acid. J Pharm Sci 1984; 73:1056-8.
3 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
4 Adler LA, et al. Long term treatment effects of vitamin E for tardive dyskinesia. Biol Psychiatry 43: 868-872, 1998
4 Inada T: [Recent research trends in diagnosis, treatment, and prevention of drug-induced extrapyramidal symptoms seen in psychiatric patients.] Nihon Shinkei Seishin Yakurigaku Zasshi, 1996 Oct, 16:5, 181-5.
5 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
5 Pronsky, Z Food Medication Interactions, 11th edition, 1999
6 Mosnik DM, Spring B, Rogers K, and Baruah SL. Tardive dyskinesia exacerbated after ingestion of phenylalanine by schizophrenic patients. Neuropsychopharmacology 16(2): 136-146, 1997.
6 Richardson MA. Amino acids in psychiatric disease. Washington, DC: American Psychiatric Press, 1990.
7 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
8 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
8 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996
9 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
10 Schelosky L, et al. Kava and dopamine antagonism. J Neurol Neurosurg Psych 58(5): 639-640, 1995
11 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
11 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996
11 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
12 Brown R. Potential interactions of herbal medicines with antipsychotics, antidepressants and hypnotics. European Journal of Herbal Medicine 1997;3:25-8.
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The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.