Data provided by Applied Health
side effects, nutrient depletions, herbal interactions and health notes:
• A preliminary study showed that taking melatonin and triazolam together produces better quality of sleep than occurs when the drug is taken alone. The results also indicated that less triazolam is needed when melatonin and triazolam are taken together, which might reduce side effects such as morning grogginess.1 Additional research is needed to determine whether individuals taking triazolam should also take melatonin.1
• In a preliminary trial, an extract of periwinkle called vinpocetine was shown to produce minor improvements in short-term memory among people taking flunitrazepam, a benzodiazepine.2 Further study is needed to determine if vinpocetine would be a helpful adjunct to use of benzodiazepines, or triazolam specifically.2
• Grapefruit juice Drinking grapefruit juice with triazolam dramatically increases the amount of drug absorbed and the amount of time it stays in the body.3 Though the clinical significance of this interaction is unknown, some people may experience increased side effects, such as morning grogginess, dizziness, and poor coordination. Therefore, people taking triazolam should probably avoid drinking grapefruit juice or eating grapefruit for the duration of therapy.3
• Pomegranate juice Pomegranate juice has been shown to inhibit the same enzyme that is inhibited by grapefruit juice.4. 5. The degree of inhibition is about the same for each of these juices. Therefore, it would be reasonable to expect that pomegranate juice might interact with triazolam in the same way that grapefruit juice does.4
• Alcohol Drinking alcoholic beverages while taking triazolam may enhance side effects such as drowsiness, confusion, and dizziness.6 Consequently, people taking triazolam should avoid drinking alcohol, especially when they must stay alert.5
• There are no herbal considerations at this time.6
References1 1. Ferini-Strambi L, Zucconi M, Biella G, et al. Effect of melatonin on sleep microstructure: preliminary results in healthy subjects. Sleep 1993;16:744–7..
2 2. Bhatti JZ, Hindmarch I. Vinpocetine effects on cognitive impairments produced by flunitrazepam. Int Clin Psychopharmacol 1987;2:325–31.
3 3. Sifton DW, ed. Physicians’ Desk Reference. Montvale, NJ: Medical Economics Company, Inc., 2000, 2461–3.
4 4. Sorokin AV, Duncan B, Panetta R, Thompson PD. Rhabdomyolysis associated with pomegranate juice consumption. Am J Cardiol 2006;98:705–6.
4 5. Summers KM. Potential drug-food interactions with pomegranate juice. Ann Pharmacother 2006;40:1472–3.
5 6. Sifton DW, ed. Physicians’ Desk Reference. Montvale, NJ: Medical Economics Company, Inc., 2000, 2461–3
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The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.