Data provided by Applied Health
side effects, nutrient depletions, herbal interactions and health notes:
• Avoid arginine with ACE inhibitors because it could cause hyperkalemia.1
• Avoid salt substitutes and be careful of using potassium and magnesium supplements, because ACEIís can raise potassium levels. Electrolytes should also be monitored regularly.2
• Monitor zinc levels, it is possible to deplete levels with ACEIís.3
• Monitor sugar levels, especially with diabetics because ACEIís can affect sugar levels.4
• Avoid or limit caffeine and alcohol.5
• These herbs may have cardiac properties which could intensify the effects of captopril : black hellebore, calamus, cereus, cola, coltsfoot, devil's claw, European mistletoe, fenugreek, fumitory, digitalis leaf, hedge mustard, figwort, lily of the valley roots, motherwort, pleurisy root, squill bulb leaf scales, white horehound, mate, scotch broom flower, shepherd's purse, and wild carrot6
• These herbs may have diuretic properties which could intensify the effects of captopril: Alfalfa, Angelica, Astragalus, Basil, Bean Pod, Buckthorn, Burdock, Butcherís Broom, Buchu, Celery, Cleavers, Cornflower, Dandelion, Elecampane, Elder, Goat's Rue, Hempnettle, Horsetail, Indian-Hemp, Juniper, Marigold, Meadowsweet, Parsley, Rauwolfia, Sarsaparilla, Sweet clover, Turmeric, and Vervain.7
References1 McKevoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998
1 Bushinsky DA, Gennari FJ. Life-threatening hyperkalemia induced by arginine. Ann Intern Med. 1978 Nov;89(5 Pt 1):632-4.
1 Doman K, Perlmutter JA, Muhammedi M, Puschett JB. Life-threatening hyperkalemia associated with captopril administration. South Med J. 1993 Nov;86(11):1269-72.
2 Burnakis TG & Mioduch HJ: Combined therapy with captopril and potassium supplementation: a potential for hyperkalemia. Arch Intern Med 1984; 144:2371-2372
2 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
2 Pronsky, Z Food Medication Interactions, 11th edition, 1999
3 Golik A, Zaidenstein R, Dishi V, et al: Effects of captopril and enalapril on zinc metabolism in hypertensive patients, J Am Coll Nutr, 1998, 17(1):75-8
4 Pronsky, Z Food Medication Interactions, 11th edition, 1999.
4 Rett K, Wicklmayr M & Dietze GJ: Hypoglycemia in hypertensive diabetic patients treated with sulfonylureas, biguanides, and captopril. N Engl J Med 1988; 319:1609.
5 Pronsky, Z Food Medication Interactions, 11th edition, 1999.
5 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
6 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998.
6 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.
6 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
6 The Review of Natural Products, Clinisphere 2.0, Wolters Kluwer Company, 2000
7 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
7 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.
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The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.