Data provided by Applied Health
side effects, nutrient depletions, herbal interactions and health notes:
• Take with food to reduce the risk of orthostatic hypotension.1
• Use with caution in diabetics, the drug may alter sugar levels.2
• Co enzyme Q-10 deficiency is possible. However, speak to a physician or pharmacist before supplementing CoQ10 due to the blood pressure lowering properties of this supplement. Reduced antihypertensive medication dosage may be needed.3
• Grapefruit juice may interact with this drug, avoid using together.4
• A low sodium and low calorie diet may be beneficial.5
• Avoid alcohol.6
• Several studies done with olive oil, have shown it can reduce blood pressure. The dosage of antihypertensive medications may need to be reduced when olive oil is consumed on a regular basis.7
• Broom, Calamus, Cereus, Cola, Coltsfoot, Devil's Claw, Fenugreek, Figwort, and Fumitory have cardioactive effects according to Newall. It may be advisable to avoid using these herbs with this medication.8
• Poplar, sweet birch, and wintergreen and willow bark all have salicylate properties which may interfere with beta blockers.9
• Avoid natural licorice products.10
• Ephedra should not be taken together with other CNS stimulants or circulatory agents (digitoxin, beta-blockers, etc.). Theoretically, a single high dose could result in irregular heartbeats.11
• Cola, Guarana, Mate are some caffeine containing herbs that should be avoided with beta blockers.12
• Beta Blockers can help to prevent Yohimbe toxicity.13
References1 Pronsky, Z Food Medication Interactions, 11th edition, 1999
1 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
2 Pronsky, Z Food Medication Interactions, 11th edition, 1999
3 Langsjoen P, Langsjoen P, Willis R, Folkers K. Treatment of essential hypertension with coenzyme Q10. Mol Aspects Med. 1994;15 Suppl:S265-72.
3 Kishi H, Kishi T, Folkers K: Bioenergetics in clinical medicine III - inhibition of coenzyme Q10-enzymes by clinically used antihypertensive drugs, Res Commun Chem Pathol Pharmacol, 1975, 12(3):533-40
4 Pronsky, Z Food Medication Interaction, 11th edition, 1999.
5 Pronsky, Z Food Medication Interactions, 11th edition, 1999
6 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
7 Ruiz-Gutierrez V, Muriana FJ, Guerrero A, Cert AM, Villar J. Plasma lipids, erythrocyte membrane lipids and blood pressure of hypertensive women after ingestion of dietary oleic acid from two different sources. J Hypertens 1996 Dec;14(12):1483-90
7 Baroni SS, Amelio M, Sangiorgi Z, Gaddi A, Battino M. Solid monounsaturated diet lowers LDL unsaturation trait and oxidisability in hypercholesterolemic (type IIb) patients. Free Radic Res. 1999 Apr;30(4):275-85.
7 Ferrara LA, Raimondi AS, d'Episcopo L, et al. Olive oil and reduced need for antihypertensive medications. Arch Intern Med 2000;160(6):837-842.
8 Facts and Comparisons, The Review of Natural Products, Clinisphere 2.0, Wolters Kluwer Company, 2000
8 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
8 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996
9 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998.
10 Pronsky, Z Food Medication Interactions, 11th edition, 1999
10 Farese, RV et al., Licorice-induced hypermineralcorticoidism. NEJM. 1991, 325:1,1223-1,227
11 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998.
12 Brinker, Francis, N.D. Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998.
13 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998.
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The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.