Data provided by Applied Health
side effects, nutrient depletions, herbal interactions and health notes:
• Supplementation with vitamin B-6 may be beneficial in correcting peripheral neuropathy caused by the drug.1
• Avoid alcohol2
• Co-Q-10 levels may be depleted by hydralazine with long term use of the medication.3
• Avoid licorice, it may raise blood pressure, cause edema and counteract the effects of hydralazine.4
• Herbs with cardioactive properties may increase side effects of hydralazine if used together. These include: black hellebore, calamus, cereus, cola, coltsfoot, devil's claw, European mistletoe, fenugreek, fumitory, digitalis leaf, hedge mustard, figwort, lily of the valley roots, motherwort, pleurisy root, squill bulb leaf scales, white horehound, mate, scotch broom flower, shepherd's purse, and wild carrot5
• Ginseng can induce a hypertensive state, and may therefore interfere with the actions of hydralazine.6
• These herbs may have diuretic properties: Alfalfa, Angelica, Astragalus, Basil, Bean Pod, Buckthorn, Burdock, Butcher’s Broom, Buchu, Celery, Cleavers, Cornflower, Dandelion, Elecampane, Elder, Goat's Rue, Hempnettle, Horsetail, Indian-Hemp, Juniper, Marigold, Meadowsweet, Parsley, Rauwolfia, Sarsaparilla, Sweet clover, Turmeric, and Vervain.7
References1 Pronsky, Z Food Medication Interactions, 11th edition, 1999
1 Thomas JA. Drug-nutrient interactions. Nutrition Rev, 1995;53(10):271-282.
1 Segal S, Kaminski S. Drug-nutrient interactions. American Druggist, July 1996:42-48.
2 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
2 Pronsky, Z Food Medication Interactions, 11th edition, 1999
3 Kishi H, Kishi T, Folkers K: Bioenergetics in clinical medicine III - inhibition of coenzyme Q10-enzymes by clinically used antihypertensive drugs, Res Commun Chem Pathol Pharmacol, 1975, 12(3):533-40.
4 Pronsky, Z Food Medication Interactions, 11th edition, 1999
4 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
5 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
5 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.
5 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
6 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
6 Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
7 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
7 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.
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The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.