Data provided by Applied Health
side effects, nutrient depletions, herbal interactions and health notes:
• The use of alcohol should be limited.1
• Grapefruit and grapefruit juice may greatly increase absorption of Procardia and possibly may cause an excessive lowering of blood pressure. It is recommended that this medication be taken with water.2
• The use of magnesium sulfate intravenously with nifedipine can result in severe hypotension.3
• Avoid natural Licorice products, Ginseng and Ephedra (Ma huang), which may contribute to hypertension.4
• The following herbs may have diuretic properties, which may increase the effects of Procardia and possibly may lead to an excessive lowering of blood pressure: Alfalfa, Angelica, Astragalus, Basil, Bean Pod, Buckthorn, Burdock, Butcherís Broom, Buchu, Celery, Cleavers, Cornflower, Dandelion, Elecampane, Elder, Goat's Rue, Hempnettle, Horsetail, Indian-Hemp, Juniper, Marigold, Meadowsweet, Parsley, Rauwolfia, Sarsaparilla, Sweet clover, Turmeric, and Vervain.5
• St. Johnís Wort may interact with some calcium channel blockers due to the use of similar pathways (eg. cytochrome P450) to metabolize the drugs and herb.6
• Some herbs possess cardiac activity and they may interact with Procardia to increase side effects: black hellebore, calamus, cereus, cola, coltsfoot, devil's claw, European mistletoe, fenugreek, fumitory, digitalis leaf, hedge mustard, figwort, lily of the valley roots, motherwort, pleurisy root, squill bulb leaf scales, white horehound, mate, scotch broom flower, shepherd's purse, and wild carrot7
References1 Mindell, E, Hopkins V: Prescription Alternatives. New Canaan, CT: Keats Publishing, Inc, 1998; p. 143.
1 Pronsky, Z Food Medication Interactions, 11th edition, 1999
2 Edgar, B et al: Acute effects of drinking grapefruit juice on the pharmacokinetics and dynamics of Felodipine--and its potential clinical relevance. Eur. J. Clin. Pharm. 1992, 42:313-317.
2 Pronsky, Z Food Medication Interactions, 11th edition, 1999
2 Bailey DG, et al. "Interaction of citrus juices with felodipine and nifedipine." Lancet, 1991; 337: 268-69.
3 Martindale W. Martindale the Extra Pharmacopoeia. Pharmaceutical Press, 1999
4 Farese, RV et al., Licorice-induced hypermineralcorticoidism. NEJM. 1991, 325:1,1223-1,227.
4 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
5 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.
5 Facts and Comparisons, Review of Natural Products, Clinisphere 2.0, Wolters Kluwer Company, 2000
5 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
6 Yue QY, Bergquist C, Gerden B. Safety of St John's wort (Hypericum perforatum). Lancet 2000;355(9203)
7 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
7 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.
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The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.