Data provided by Applied Health
side effects, nutrient depletions, herbal interactions and health notes:
• Estrace may increase risk of folic acid deficiency, which could affect reproductive and cardiovascular health. Supplementation is considered beneficial with long term use of the medication.1
• Estrace may affect absorption of the certain B vitamins, magnesium, and zinc. Supplementation of these nutrients may be beneficial with long term use of the medication.2
• Vitamin C may result in increased estrogen effects.3
• Talk to your doctor about calcium supplementation, exercise, and periodic bone density screenings with long term use of the medication.4
• Avoid grapefruit juice with this medication, it may increase drug levels.5
• The following herbs may affect hormone levels: Agnus Castus (Vitex), Alfalfa, Bayberry, Black Cohosh, Dong Quai, Ginseng, Horseradish, Kelp, Licorice Root, Motherwort, Pleurisy Root, Red Clover, Red Sage, Saw Palmetto, Vervain, Wild Carrot Seed, and WildYam. Many herbs many interact with hormone replacement. Consult your pharmacist for more information.6
References1 Roe DA. Nutrition and the contraceptive pill. In: Winick M, ed. Nutritional Disorders of American Women. New York: John Wiley and Sons; 1977:37-49.
1 Lindenbaum J, Whitehead N, Reyner F. Oral contraceptive hormones, folate metabolism, and the cervical epithelium. Am J Clin Nutr 1975;28:346-53.
1 Kornberg A, Segal R, Theitler J, et al: Folic acid deficiency, megaloblastic anemia and peripheral polyneuropathy due to oral contraceptives, Isr J Med Sci, 1989, 25 (3): 142-5.
1 Harper JM, Levine AJ, Rosenthal DL, et al: Erythrocyte folate levels, oral contraceptive use and abnormal cervical cytology, Acta Cytol, 1994, 38 (3): 324-30.
2 Zava, DT: Estrogen and progestin bioactivity of foods, herbs and spices. Proc. Soc. Exp. Biol. Med. 1998, 217:369-378.
2 Adams PW, Wynn V, Rose DP, et al. Effect of pyridoxine hydrochloride (vitamin B6) upon depression associated with oral contraception. Lancet 1973;I:897-904.
2 Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197-98.
2 Blum M, Kitai E, Ariel Y, Et Al: Oral Contraceptive Lowers Serum Magnesium, Harefuah, 1991, 121 (10):363-4.
2 Seelig Ms, Interrelationship Of Magnesium And Estrogen In Cardiovascular And Bone Disorders, Eclampsia, Migraine, And Premenstrual Syndrome, J Am Coll Nutr, 1993, 12(4):442-58.
2 Webb JL, Nutritional effects of oral contraceptive use, a review, J Reprod Med, 1980, 25 (4): 150-6.
3 Rybacki, JM. The Concise Guide to Prescription Drugs. Harper, 1997.
3 Pronsky, Z Food Medication Interactions, 11th edition, 1999
4 Rybacki, JM. The Concise Guide to Prescription Drugs. Harper, 1997.
4 Pronsky, Z Food Medication Interactions, 11th edition, 1999
5 Schubert W, Cullberg G, Edgar B, Hedner T. Inhibition of 17 beta-estradiol metabolism by grapefruit juice in ovariectomized women. Maturitas 1994;20:155-63.
6 Ferguson T: The Smokerís Book of Health, G.P. Putnamís Sons, New York, 1987.
6 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
6 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.
6 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
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The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.