Data provided by Applied Health
side effects, nutrient depletions, herbal interactions and health notes:
• Pravachol may cause gastrointestinal upset. It may be beneficial to increase your intake of fluids.1
• Alcohol use should be limited.2
• This medication has been shown to displace coenzyme Q10, a nutrient important for energy and cardiovascular support. Supplementation with coenzyme Q10 is considered beneficial with long term use of the drug.3
• These herbs may decrease blood cholesterol levels and enhance the effects of Pravachol: Artichoke plant, Fenugreek, Garlic and Plaintain.4
• Avoid red yeast rice with pravachol due to possible additive effects or increased side effects.5
References1 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
1 Pronsky, Z Food Medication Interactions, 11th edition, 1999
2 Pronsky, ZM, et al: Food-Medication Interactions, Pottstown, PA, 11th edition, 1999
3 Ghirlanda, G. et al: Evidence of plasma CoQ10-lowering effect by HMG-CoA reductase inhibitors: a double blind, placebo-controlled study. J. Clin. Pharm. 1993, 33(3):226-9.
3 Mortensen SA, Leth A, Agner E, Rohde M. Dose-related decrease of serum coenzyme Q10 during treatment with HMG-CoA reductase inhibitors. Mol Aspects Med 1997;18(suppl):S137-44.
3 De Pinieux G, Chariot P, Ammi-Said M, et al: Lipid lowering drugs and mitochondrial function – effects of HMG-CoA Reductase Inhibitors on serum upiquinone and blood lactate/pyruvate ratio, Br J Pharmacol, 1996, 42(3):333-7.
3 Bargossi Am, Grossi G, Fiorella PL, et al: Exogenous CoQ10 supplementation prevents plasma ubiquinone reduction induced by HMG-CoA reductase inhibitors, Mol Aspects Med, 1994, 15 (suppl):187-93.
4 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.
4 Facts and Comparisons, Review of Natural Products, Clinisphere 2.0, Wolters Kluwer Company, 2000
4 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
5 Heber D, Yip I, Ashley Jm, et al. Cholesterol-lowering effects of a proprietary Chinese red-yeast-rice dietary supplement. Am J Clin Nutr 1999;69:231-36.
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The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.