Data provided by Applied Health
side effects, nutrient depletions, herbal interactions and health notes:
• Avoid consuming excessive potassium in foods and supplements when taking Zestril. Ask your physician or pharmacist for more information regarding electrolyte balance.1
• The use of alcohol should be limited.2
• Zestril may contribute to a deficiency in zinc. Supplementation may be beneficial.3
• Separate magnesium and iron supplements from the drug by at least 2 hours.4
• Some herbs possess diuretic properties that may intensify the action of Zestril and may lead to an excessive lowering of blood pressure. Such herbs include: Alfalfa, Angelica, Astragalus, Basil, Bean Pod, Buckthorn, Burdock, Butcher’s Broom, Buchu, Celery, Cleavers, Cornflower, Dandelion, Elecampane, Elder, Goat's Rue, Hempnettle, Horsetail, Indian-Hemp, Juniper, Marigold, Meadowsweet, Parsley, Rauwolfia, Sarsaparilla, Sweet clover, Turmeric, and Vervain.5
• Avoid natural licorice products, Ginseng and Ephedra (Ma huang), which may interfere with antihypertensive medications like zestril.6
• Capsaicin may increase the cough associated with use of ACE inhibitors like zestril. Avoid using both of these agents together.7
References1 Burnakis TG & Mioduch HJ: Combined therapy with captopril and potassium supplementation. A potential for hyperkalemia. Arch Intern Med 1984; 144:2371-2372.
1 Good CB, McDermott L, McCloskey B. Diet and serum potassium in patients on ACE inhibitors. JAMA 1995;274:538.
1 Pronsky, Z Food Medication Interactions, 11th edition, 1999
1 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
2 Pronsky, ZM: Food-Medication Interactions, 11th edition, 1999
2 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
3 Golik A, Zaidenstein R, Dishi V, et al: Effects of captopril and enalapril on zinc metabolism in hypertensive patients, J Am Coll Nutr, 1998, 17(1):75-8.
3 Golik A, Modai D, Averbukh Z, et al: Zinc metabolism in patients treated with captopril versus enalapril, Metabolism, 1990, 39(7): 665-7.
4 Campbell NR and Hasinoff BB. Iron supplements: A common cause of drug interactions. Br J Clin Pharmacol 31: 251-255, 1991.
4 Pronsky, Z Food Medication Interactions, 11th edition, 1999
4 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
5 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.
5 Facts and Comparisons, The Review of Natural Products, Clinisphere 2.0, Wolters Kluwer Company, 2000
5 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
6 Pronsky, ZM: Food-Medication Interactions, 11th edition, 1999
6 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
7 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
Want more special reports like this e-mailed to you when they're available? Click here for free e-mail alerts.
Share this Special Report by linking to it
Copy and paste the following HTML code into any web page:
The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.