Sildenafil
side effects, nutrient depletions, herbal interactions and health notes:
Data provided by Applied Health
• In one study, ingestion of 250 ml (approximately 1 cup) of grapefruit juice one hour before and together with sildenafil increased the total amount of sildenafil absorbed by 23%, but tended to delay the absorption of the drug.1 The authors of this study recommended that sildenafil and grapefruit juice not be taken together.1
• Pomegranate juice has been shown to inhibit the same enzyme that is inhibited by grapefruit juice.2 3 The degree of inhibition is about the same for each of these juices. Therefore, it would be reasonable to expect that pomegranate juice might interact with sildenafil in the same way that grapefruit juice does.2
• In evaluating 105 men (mean age of 66 years) with erectile dysfunction with known or highly suspected coronary artery disease, subjects underwent 2 symptom-limited supine bicycle echocardiograms separated by an interval of 1 to 3 days after receiving a single dose of sildenafil (Viagra) at 50 or 100 mg or a placebo 1 hour before each exercise test. It was found that in men with stable coronary artery disease, sildenafil had no effect on symptoms, exercise duration, or the presence or extent of exercise-induced ischemia, as evaluated by exercise echocardiography. Sildenafil is a cyclic guanosine monophosphate-specific type 5 phosphodiesterase inhibitor.3
References1 1. Jetter A, Kinzig-Schippers M, Walchner-Bonjean M, et al. Effects of grapefruit juice on the pharmacokinetics of sildenafil. Clin Pharmacol Ther 2002;71:21–9.
2 Pomegranate juice has been shown to inhibit the same enzyme that is inhibited by grapefruit juice.2 3 The degree of inhibition is about the same for each of these juices. Therefore, it would be reasonable to expect that pomegranate juice might interact with sildenafil in the same way that grapefruit juice does.
2 3. Summers KM. Potential drug-food interactions with pomegranate juice. Ann Pharmacother 2006;40:1472–
3 Cardiovascular Effects of Sildenafil During Exercise in Men With Known or Probable Coronary Artery Disease: A Randomized Crossover Trial," Arruda-Olson AM, Mahoney DW, Nehra A, et al, JAMA, February 13, 2002;287(6):719-725.
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Disclaimers
The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.
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