Data provided by Applied Health
side effects, nutrient depletions, herbal interactions and health notes:
• A high fiber, low salt and calorie diet may be beneficial in hypertension.1
• The diuretic drug in this combination product (hydrochlorothiazide) is known to deplete potassium and magnesium levels. Losartan, the other medication in this combination, may retain potassium, thus offsetting the electrolyte effects of hydrochlorothiazide. It is important to monitor electrolyte levels.2
• Supplementation with zinc may be beneficial due to urinary loss. Consult with your pharmacist for more information.3
• Cascara Sagrada, Rhubarb and Senna may increase potassium loss caused by Hyzaar.4
• Avoid natural Licorice products, Ginseng, and Ephedra (Ma huang), which may interfere with antihypertensive medications.5
• The following herbs possess cardiac properties that may intensify the effects of this drug: black hellebore, calamus, cereus, cola, coltsfoot, devil's claw, European mistletoe, fenugreek, fumitory, digitalis leaf, hedge mustard, figwort, lily of the valley roots, motherwort, pleurisy root, squill bulb leaf scales, white horehound, mate, scotch broom flower, shepherd's purse, and wild carrot6
References1 Pronsky, Z Food Medication Interactions, 11th edition, 1999
2 Whang R, Whang DD, Ryan MP. Refractory potassium repletion-a consequence of magnesium deficiency. Arch Intern Med 1992;152:40-45.
2 Martin B, Milligan K. Diuretic-associated hypomagnesiumia in the elderly. Arch Intern Med 1987;147:1768-71.
2 Quamme GA: Renal magnesium handling - New insights in understanding old problems, Kidney Int, 1997, 52(5):1180-95.
2 Schwinger RH, Erdmann E: Heart failure and electrolyte disturbances, Methods Find Exp Clin Pharmacol, 1992, 14(4):315-25.
2 Linderman RD: Hypokalemia - causes, consequences, and correction, Am J Med Sci, 1976, 272(1):5-17.
2 Lucker PW, Witzmann HK: Influence of magnesium and potassium deficiency on renal elimination and cardiovascular function demonstrated by impedance cardiography, Magnesium, 1984, 3(4-6):265-73.
3 Roe, DA: Handbook on Drug and Nutrient Interactions, 5th edition, 1994.
3 Wester PO: Urinary zinc excretion durign treatment with different diuretics, Acta Med Scand, 1980, 208(3):209-12.
4 De Smet PAGM et al: Adverse effects of herbal drugs 2, 1993.
4 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
4 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
5 Wichtl M: Herbal Drugs and Phytopharmaceuticals, 1994.
5 Shintani S, Murase H, Tsukagoshi H, Shiigai T. Glycyrrhizin (licorice)-induced hypokalemic myopathy. Report of two cases and review of the literature. Eur Neurol 1992;32:44-51.
5 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
6 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.
6 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
6 Facts and Comparisons, The Review of Natural Products, Clinisphere 2.0, Wolters Kluwer Company, 2000
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The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.