Data provided by Applied Health
side effects, nutrient depletions, herbal interactions and health notes:
• The following nutrients or ions may be depleted with long-term use of cholestyramine: beta-carotene, folic acid, calcium, magesium, iron, zinc, vitamins A, D, E, and K. Supplementation, especially with folic acid may be beneficial.1
• Cholestyramine may cause malabsorption of other drugs/nutritional supplements and should be separated from them by four to six hours.2
• The medication should be taken before meals.3
• Decrease fat and cholesterol intake while using this drug.4
• Consume adequate fluids, especially water, unless otherwise directed.5
• The following herbs may interact with cholestyramine due to the known interaction between anticoagulants and cholestyramine: Angelica, Anise, Arnica, Asafoetida, Bogbean, Boldo, Capsicum, Celery chamomile, Clove, Danshen, Fenugreek, Feverfew, Garlic, Ginger, Ginseng (Panax), Horse chestnut, Horse radish, Meadowsweet, Prickly ash, Onion, Papain, Turmeric, Wild carrot, Wild lettuce, and Willow.6
• Avoid these herbs with cholestyramine due to possible additive effects: Artichoke plant, fenugreek, garlic and plantain.7
References1 Pronsky, Z Food Medication Interactions, 11th edition, 1999.
1 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000.
1 Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 221-22.
1 Probstfield JL, Lin T, Peters J, Hunninghake DB. Carotenoids and vitamin A: The effect of hypocholesterolemic agents on serum levels. Metabolism 1985; 34: 88-91.
1 Hoppner K, Lampi B. Bioavailability of folate following ingestion of cholestyramine in the rat. Int J Vitam Nutr Res 61: 130-134, 1991.
1 West RJ, Lloyd JK. The effect of cholestyramine on intestinal absorption. Gut 16: 93-98, 1975.
1 McKevoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 2000.
1 AMA Drug Evaluations, 1995 Ann, Chicago, IL, Amer Med Assoc, 1995
2 Pronsky, Z Food Medication Interactions, 11th edition, 1999.
2 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000.
3 Pronsky, Z Food Medication Interactions, 11th edition, 1999.
3 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000.
4 Pronsky, Z Food Medication Interactions, 11th edition, 1999.
5 Pronsky, Z Food Medication Interactions, 11th edition, 1999
6 Fetrow CW, Avila JR. Professional's handbook of complementary and alternative medicines. First ed. Springhouse: Springhouse Corporation, 1999.
6 Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
6 Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
6 Facts and Comparisons, Review of Natural Products, Clinisphere 2.0, Wolters Kluwer Company, 2000.
7 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
7 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.
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The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.