Data provided by Applied Health
side effects, nutrient depletions, herbal interactions and health notes:
• Grapefruit juice may increase the effects of Invirase and a dosage adjustment may need to be made.1
• Invirase should be taken within two hours of a meal to be effective.2
• St. John's Wort may decrease the effect of protease inhibitors like invirase. Avoid using these two agents together.3
• The following herbs: calamus, calendula, chamomile, California poppy, catnip, couch grass, elecampane, ginseng (Siberian), goldenseal, gotu kola, hops, Jamaican dogwood, kava, lemon balm, sage, sassafras, scullcap, shepherd's purse, stinging nettle, valerian, withania root, and yerba mansa have sedative or hynotic effects. In view of known interactions between certain sedative hynotics and invirase, consult your physician or pharmacist before using these4
• Astragalus may interact and enhance side effects of antiviral agents such as invirase.5
References1 Kupferschmidt HH, Fattinger KE, Ha HR, Follath F, Krahenbuhl S. Grapefruit juice enhances the bioavailability of the HIV protease inhibitor saquinavir in man.Br J Clin Pharmacol 1998 Apr;45(4):355-9
1 Bailey DG, Malcolm J, Arnold O, Spence JD. Grapefruit juice-drug interactions. Br J Clin Pharmacol. 1998 Aug;46(2):101-10.
1 Eagling VA, Profit L, Back DJ. Inhibition of the CYP3A4-mediated metabolism and P-glycoprotein-mediated transport of the HIV-1 protease inhibitor saquinavir by grapefruit juice components. Br J Clin Pharmacol. 1999 Oct;48(4):543-52.
2 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
3 Yue QY, Bergquist C, Gerden B. Safety of St John's wort (Hypericum perforatum). Lancet 2000;355(9203):576-7.
3 Risk of drug interactions with St. John's wort and indinavir and other drugs. URL: www.fda.gov/cder/drug/advisory/stjwort.htm
4 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
4 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
5 The Review of Natural Products, Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
5 Upton R (ed). Astragalus Root: analytical, quality control, and therapeutic monograph. Santa Cruz, CA: American Herbal Pharmacopoeia; 1999;1-25
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The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.