Data provided by Applied Health
side effects, nutrient depletions, herbal interactions and health notes:
• Take with food to reduce gastrointestinal irritation.1
• Avoid alcohol.2
• Use of this medication with watercress decreases elimination of the drug and thus, may cause an elevation of the drug's effects.3
• The sedative properties of these herbs may increase CNS side effects of chlorzoxazone : calamus, calendula, california poppy,catnip, couch grass, elecampane, siberian ginseng , chamomile (german), goldenseal, gotu kola, hops, jamaican dogwood, kava, lemon balm, sage, sweet bay, st. john's wort, sassafras, scullcap, shepherd's purse, stinging nettle, valerian,wild carrot, wild lettuce, withania root, and yerba mansa.4
References1 Pronsky, Z Food Medication Interactions, 11th edition, 1999.
1 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000.
2 Pronsky, Z Food Medication Interactions, 11th edition, 1999.
2 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000.
3 Pronsky, Z Food Medication Interactions, 11th edition, 1999.
3 Leclercq I, Desager JP, Horsmans Y. "Inhibition of chlorzoxazone metabolism, a clinical probe for CYP2E1, by a single ingestion of watercress". Clin Pharmacol Ther, 1998; 64:144-149.
4 Fetrow CW, Avala JR. Professional's Handbook of Complementary and Alternative Medicines. Springhouse Corporation, 1999.
4 Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
4 Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
4 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000.
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The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.