Data provided by Applied Health
side effects, nutrient depletions, herbal interactions and health notes:
• Alcohol can dangerously interact with this medication.1
• Take with food or milk to avoid stomach upset.2
• Large doses of vitamin C (3000mg)/day can interact with acetaminophen to prolong its effect. A dosage reduction may be necessary.3
• Herbs with sedative properties like: Calamus, Calendula, California poppy, Catnip, Couch grass, Elecampane, Chamomile (German), Jamaican dogwood, Kava, Lemon balm, Sage, St. John's wort, Sassafras, Shepherd's purse, Stinging nettle, Valerian, Withania, and Yerba mansa may increase the effects or side effects of Hydrocodone/APAP.4
• Milk Thistle Extract helps prevent liver damage from hepatotoxins, including acetaminophen.5
• Tobacco reduces blood levels of acetaminophen.6
References1 Mindell, E, Hopkins V: Prescription Alternatives. New Canaan, CT: Keats Publishing, Inc, 1998; p. 263.
1 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
1 Pronsky, Z Food Medication Interactions, 11th edition, 1999
2 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
2 Pronsky, Z Food Medication Interactions, 11th edition, 1999
3 Houston JB, Levy G. Drug biotransformation interactions in man. VI: Acetaminophen and ascorbic acid. J Pharm Sci 1976;65:121-21.
4 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.
4 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
5 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
5 Campos, R. et al. Silybin Dihemisuccinate protects against glutathione depletion and lipid peroxidation induced by acetaminophen on rat liver. Planta Medica. 1989: 55:417.
6 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
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The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.