Data provided by Applied Health
side effects, nutrient depletions, herbal interactions and health notes:
• Tricyclic antidepressants like desipramine may deplete Co-Q-10 levels in the body.1
• Tricyclics may deplete vitamin B2 or riboflavin.2
• Avoid or limit caffeine and alcohol.3
• High fiber diet may decrease efficacy of the drug.4
• Tobacco may increase the elimination time of tricyclic antidepressants.5
• Tricyclic antidepressants may have additive anticholinergic effects if used with thorn apple or jimson weed.6
• Tricyclic antidepressants may increase serotonergic side effects if combined with SAMe.7
• Yohimbe may interact with tricyclic antidepressants and increase blood pressure.8
• The German Commission E has noted a potential for an interaction between tricyclic agents and these herbs: Belladonna leaf and root, Henbane leaf, Kava Kava, Scopolia root9
References1 Folkers K. Basic chemical research on coenzyme Q10 and integrated clinical research on therapy of diseases. As cited in Lenaz G (ed.). Coenzyme Q. New York: John Wiley and Sons, 1985
1 Kishi T, et al, "Inhibition of Myocardial Respiration by Psychotherapeutic Drugs and Prevention by Coenzyme Q," Biomedical and Clinical Aspects of Coenzyme Q, Yamamura Y, Folkers K, and Ito Y, eds, Elsevier/North Holland Biomedical Press: Amsterdam, 1980, Vol 2, 139-54.
2 Bell IR, Edman JS, Morrow FD, et al: Brief communication - Vitamin B1, B2, and B6 augmentation of tricyclic antidepressant treatment in geriatric depression with cognitive function, J Am Coll Nutr, 1992, 11(2):159-63
2 Pinto, J.T. & Rivlin, R.S. : Drugs that promote renal excretion of riboflavin. Drug Nutrient Interactions, 1987, 5: 143-151
2 Pronsky, Z Food Medication Interactions, 11th edition, 1999
3 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
3 Pronsky, Z Food Medication Interactions, 11th edition, 1999
4 Pronsky, Z Food Medication Interactions, 11th edition, 1999
5 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
6 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
7 Berlanga C, et al. "Efficacy of S-adenosyl-L-methionine in speeding the onset of action of imipramine." Psychiatry Res, 1992; 44(3):257-62.
7 Iruela LM, et al. Toxic interaction of S-adenosylmethionine and clomipramine. Am J Psych 1993; 150:522.
8 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
9 Blumenthal, M (Ed.): The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. American Botanical Council. Austin, TX. 1998
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The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.