Data provided by Applied Health
side effects, nutrient depletions, herbal interactions and health notes:
• This is a combination diuretic drug. One component, hydrochlorothiazide, is known to deplete potassium, and this depletion also affects magnesium levels. However, the other component, triamterene, acts to retain potassium. You should seek advice from your physician or pharmacist before supplementing potassium or magnesium.1
• Other nutrients may be lost due to increased urinary excretion. Sodium, Co-Q-10 and zinc may be depleted. Consult with your doctor/pharmacist for more information about vitamin and mineral supplementation.2
• Dyazide may interact with the herbs: black hellebore, calamus, cereus, cola, coltsfoot, devil's claw, fumitory, digitalis leaf, hedge mustard, figwort, lily of the valley roots, motherwort, pleurisy root, squill bulb leaf scales, white horehound, mate, scotch broom flower, shepherd's purse, and wild carrot3
• Cascara Sagrada, Rhubarb and Senna may increase potassium loss caused by Dyazide.4
• Avoid natural Licorice products which may contribute to fluid retention.5
• These herbs may have diuretic properties which could intensify the effects of dyazide: Alfalfa, Angelica, Astragalus, Basil, Bean Pod, Buckthorn, Burdock, Butcher’s Broom, Buchu, Celery, Cleavers, Cornflower, Dandelion, Elecampane, Elder, Goat's Rue, Hempnettle, Horsetail, Indian-Hemp, Juniper, Marigold, Meadowsweet, Parsley, Rauwolfia, Sarsaparilla, Sweet clover, Turmeric, and Vervain.6
References1 Whang R, Whang DD, Ryan MP. Refractory potassium repletion - a consequence of magnesium deficiency. Arch Intern Med 1992;152:40-45.
1 Martin B, Milligan K. Diuretic-associated hypomagnesiumia in the elderly. Arch Intern Med 1987;147:1768-71.
1 Quamme GA: Renal magnesium handling - New insights in understanding old problems, Kidney Int, 1997, 52(5):1180-95.
1 Schwinger RH, Erdmann E: Heart failure and electrolyte disturbances, Methods Find Exp Clin Pharmacol, 1992, 14(4):315-25.
1 Linderman RD: Hypokalemia - causes, consequences, and correction, Am J Med Sci, 1976, 272(1):5-17.
1 Lucker PW, Witzmann HK: Influence of magnesium and potassium deficiency on renal elimination and cardiovascular function demonstrated by impedance cardiography, Magnesium, 1984, 3(4-6):265-73.
2 Roe, DA: Handbook on Drug and Nutrient Interactions, 5th edition, 1994.
2 Brady JA, Rock CL, Horneffer MR: Thiamin status, diuretic medications, and the management of congestive heart failure, J Am Diet Assoc, 1995, 95(5):541-4.
2 Mydlik M, Derzsiova K, Zemberova E, et al: Metabolism of vitamin B6 and its requirement in chronic renal failure, Kidney Int Suppl, 1997, 62:S56-9.
2 Wester PO: Urinary zinc excretion durign treatment with different diuretics, Acta Med Scand, 1980, 208(3):209-12.
2 Riis B, Christiansen C. Actions of thiazide on vitamin D metabolism: A controlled therapeutic trial in normal women early in the postmenopause. Metabolism 1985;34:421-24.
2 Reyes AJ, Leary WP, Lockett CJ, et al. Diuretics and zinc. S Afr Med J 1982;62:373-75.
2 Kishi H, et al. Bioenergetics in clinical medicine. III. Inhibition of coenzyme Q10-enzymes by clinically used anti-hypertensive drugs. Res Commun Chem Pathol Pharmacol 12(3): 533-540, 1975
3 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.
3 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
3 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
4 De Smet PAGM et al: Adverse effects of herbal drugs 2, 1993.
4 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
5 Wichtl M: Herbal Drugs and Phytopharmaceuticals, 1994.
5 Shintani S, Murase H, Tsukagoshi H, Shiigai T. Glycyrrhizin (licorice)-induced hypokalemic myopathy. Report of two cases and review of the literature. Eur Neurol 1992;32:44-51.
5 Pronsky, Z Food Medication Interactions, 11th edition, 1999
6 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
6 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.
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The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.