Data provided by Applied Health
side effects, nutrient depletions, herbal interactions and health notes:
• The use of alcohol should be limited.1
• Accupril may contribute to zinc deficiency with long term use. Discuss the need for supplementation with a pharmacist.2
• Avoid consuming excessive potassium in foods and supplements while taking Accupril. Ask your physician or pharmacist for more information about electrolyte balance.3
• Some herbs possess cardiac activity and they may interact with Accupril to increase side effects: black hellebore, calamus, cereus, cola, coltsfoot, devil's claw, European mistletoe, fenugreek, fumitory, digitalis leaf, hedge mustard, figwort, lily of the valley roots, motherwort, pleurisy root, squill bulb leaf scales, white horehound, mate, scotch broom flower, shepherd's purse, and wild carrot4
• Avoid natural licorice products, Ginseng, and Ephedra (Ma huang) which may interfere with antihypertensive therapy.5
• These herbs may possess diuretic properties which could result in additive effects with accupril. They include: Alfalfa, Angelica, Astragalus, Basil, Bean Pod, Buckthorn, Burdock, Butcher’s Broom, Buchu, Celery, Cleavers, Dandelion, Elecampane, Elder, Goat's Rue, Hempnettle, Horsetail, Indian-Hemp, Juniper, Marigold, Meadowsweet, Parsley, Rauwolfia, Sarsaparilla, Sweet clover, Turmeric, and Vervain6
References1 Pronsky, ZM: Food-Medication Interactions, 11th edition, 1999
1 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
2 Golik A, Zaidenstein R, Dishi V, et al: Effects of captopril and enalapril on zinc metabolism in hypertensives, J Am Coll Nutr, 1998, 17(1):75-8.
2 Golik A, Modai D, Averbukh Z, et al: Zinc metabolism in patients treated with captopril versus enalapril, Metabolism, 1990, 39(7): 665-7.
3 Burnakis TG & Mioduch HJ: Combined therapy with captopril and potassium supplementation. A potential for hyperkalemia. Arch Intern Med 1984; 144:2371-2372.
3 Good CB, McDermott L, McCloskey B. Diet and serum potassium on ACE inhibitors. JAMA 1995;274:538.
3 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
4 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.
4 The Review of Natural Products, Clinisphere 2.0, Wolters Kluwer Company, 2000
4 Blumenthal M, et al. ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
4 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
5 Pronsky, ZM: Food-Medication Interactions, 11th edition, 1999
5 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
6 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
6 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.
6 Blumenthal M, et al. ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
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The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.