Data provided by Applied Health
side effects, nutrient depletions, herbal interactions and health notes:
• Zinc, selenium, and the amino acids (glutamic acid, alanine and glycine) may be beneficial.1
• Avoid caffeine, alcohol and spicy foods.2
• A number of herbs have hormonal activity. BPH is a special case in that anti-androgenic activity is desired, rather than androgen i.e. male hormones. Major herbs are: African pygeum, nettle, and saw palmetto. It is possible to have additive effects with Proscar and these herbs.3
• Herbs with steroid components may increase side effects e.g. Sarsaparilla.4
• A plant source, beta-sitosterol has shown some evidence of helping improve some symptoms of benign prostatic hypertrophy. Since finasteride is also used for BPH, do not use both agents together without consulting a physician.5
• Cernilton, a rye pollen may improve symptoms of BPH, avoid using this with Proscar without consulting a physician. There may be additive effects.6
References1 Dumrau, F., "Benign Prostatic Hyperplasia: Amino Acid Therapy for Symptomatic Relief", Am J Geriatrics 10:426-30, 1962
1 Schrodt, GR, et al, "The Concentration of Zinc in Diseased Human Prostate Glands", Cancer 17:1555-66, 1964
1 Webber, MM, "Selenium Prevents the Growth Stimulatory Effects of Cadmium on Human Prostatic Epithelium", Biochem Biophy res Commun 127(3):871-77, 1985
2 Germano, Carl M.A.,R.D.,CNS, Nutritional Considerations in Benign Prostate Enlargement 1995.
3 Bassi, P., et al, "Standardized Extract of Pygeum africanum in the Treatment of Benign Prostatic Hypertrophy", Minerva Urologica 39:45, 1987
3 Carilla, E., et al, "Binding of Permixon (Saw Palmetto Extract), A New Treatment For Prostatic Benign Hyperplsia", J Steroid Biochem 20 (1): 521-523, 1984
3 Carraro JC, Raynaud JP, Koch G, et al. Comparison of phytotherapy (Permixon®) with finasteride in the treatment of benign prostate hyperplasia: A randomized international study of 1,098 patients. Prostate 1996;29:231-40.
3 Wilt TJ, Ishani A, Stark G, et al. Saw palmetto extracts for treatment of benign prostatic hyperplasia. A systematic review. JAMA 1998;280:1604-1609.
3 Braeckman J, Bruhwyler J, Vandekerckhove K, Géczy J. Efficacy and safety of the extract of Serenoa repens in the treatment of benign prostatic hyperplasia:Therapeutic equivalence between twice and once daily dosage forms. Phytotherapy Res 1997;11:558-63.
3 Koch E, Biber A. Pharmacological effects of sabal and urtica extracts as a basis for a rational medication of benign prostatic hyperplasia. Urologe 1994;334:90-95.
3 Metzker H, Kieser M, Hölscher U. Efficacy of a combined Sabal-Urtica preparation in the treatment of benign prostatic hyperplasia (BPH). Urologe [B] 1996;36:292-300
4 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996
5 Berges RR, Windeler J, Trampisch HJ, et al. Randomized, placebo-controlled, double-blind clinical trial of beta-sitosterol in patients with benign prostatic hyperplasia. Lancet 1995;345:1529-32.
5 Klippel KF, Hiltl DM, Schipp B. A multicentric, placebo-controlled, double-blind clinical trial of ß-sitosterol (phytosterol) for the treatment of benign prostatic hyperplasia. Br J Urol 1997;80:427-32.
6 Horii A, Iwai S, Maekawa M, Tsujita M. Clinical evaluation of Cernilton in the treatment of the benign prostatic hypertrophy. Hinyokika Kiyo 1985;31:739-45 (in Japanese).
6 Nakase K, Takenaga K, Hamanaka T, et al. Inhibitory effect and synergism of cernitin pollen extract on the urethral smooth muscle and diaphragm of the rat. Nippon Yakurigaku Zasshi 1988 Jun;91(6):385-92 [in Japanese].
6 Suzuki T, Kurokawa K, Mashimo T, et al. Clinical effect of Cernilton in chronic prostatitis. Hinyokika Kiyo 1992;38:489-94 [in Japanese].
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The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.