Data provided by Applied Health
side effects, nutrient depletions, herbal interactions and health notes:
• Extended use of Ortho Tri-Cyclen may cause deficiencies in folic acid, pyridoxine, magnesium, zinc, and vitamins B2, B12, and C. Supplementation may be recommended with long term use of the medication.1
• Ortho Tri-Cyclen may cause levels of vitamin E, vitamin A, and calcium to increase. It is recommended that you discuss the proper levels of these nutrients with your physician or pharmacist.2
• Caffeine intake should be limited. Hormonal contraceptive agents may increase the effect of caffeine.3
• The following herbs possess antidiabetic properties that may be decreased if oral contraceptives are used in combination with them: Dandelion, Guar, Juniper, Nettle, and Onion plant4
• The following herbs may be hormonally active and could disturb the action of Ortho-tri-Cyclen: Agnus castus, Bayberry, Black Cohosh, Ginseng, Horseradish, Red Clover, Saw Palmetto, Vervain, Wild Yam.5
• Avoid cola, cocoa, green tea, guarana, and mate with this medication due to their caffeine content.6
References1 Van Nostrand Reinhold: Oral contraceptives and nutrient interactions, 1988:38.
1 Lindenbaum J, Whitehead N, Reyner F. Oral contraceptive hormones, folate metabolism, and the cervical epithelium. Am J Clin Nutr 1975;28:346-53.
1 Frassinelli-Gunderson EP, Margen S, Brown JR. Iron stores in users of oral contraceptive agents. Am J Clin Nutr 1985;41(4):703.
1 Adams PW, Wynn V, Rose DP, et al. Effect of pyridoxine hydrochloride (vitamin B6) upon depression associated with oral contraception. Lancet 1973;I:897-904.
1 Wynn V. Vitamins and oral contraceptive use. Lancet 1975;1:561-64.
1 Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197-98.
1 Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 210-11 [review].
1 Kornberg A, Segal R, Theitler J, et al: Folic acid deficiency, megaloblastic anemia and peripheral polyneuropathy due to oral contraceptives, Isr J Med Sci, 1989, 25 (3): 142-5.
1 Harper JM, Levine AJ, Rosenthal DL, et al: Erythrocyte folate levels, oral contraceptive use and abnormal cervical cytology, Acta Cytol, 1994, 38 (3): 324-30.
1 Blum M, Kitai E, Ariel Y, Et Al: Oral Contraceptive Lowers Serum Magnesium, Harefuah, 1991, 121 (10):363-4.
1 Seelig Ms, Interrelationship Of Magnesium And Estrogen In Cardiovascular And Bone Disorders, Eclampsia, Migraine, And Premenstrual Syndrome, J Am Coll Nutr, 1993, 12(4):442-58.
1 Webb JL, Nutritional effects of oral contraceptive use, a review, J Reprod Med, 1980, 25 (4): 150-6.
1 Prasad AS, Lei KY, Moghissi KS, et al: Effect of oral contraceptives on nutrients III--Vitamins B6, B12, and folic acid, Am J Obstet Gynecol, 1976, 125(8):1063-9.
1 Bhagavan HN, Brin M: Drug-Vitamin B6 Interaction, Curr Concepts Nutr, 1983, 12:1-12.
1 Kishi H, Kishi T, Williams RH, et al: Deficiency of vitamin B6 in women taking contraceptive formulations, Res Commun Chem Pathol Pharmacol, 1997, 17(2):283-93.
1 Rivers JM: Oral contraceptives and ascorbic acid, Am J Clin Nutr, 1975, 28(5):550-4.
1 Weininger J, King JC: Effect of oral contraceptive agents on ascorbic acid metabolism in the rhesus monkey, Am J Clin Nutr, 1982, 35(6):1408-16.
1 Muneyvirci-Delale O, Nacharaju VL, Altura BM, et al: Sex steroid hormones modulate serum ionized magnesium and calcium levels throughout the menstrual cycle in women, Gertil Steril, 1998, 69(5):958-62.
2 Pronsky, ZM: Food-Medication Interactions, 11th edition, 1999
2 Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 210-11 [review].
2 Wynn V. Vitamins and oral contraceptive use. Lancet 1975;1:561-64.
2 Webb JL, Nutritional effects of oral contraceptive use, a review, J Reprod Med, 1980, 25 (4): 150-6.
3 Graedon J, Graedon, T: The People’s Guide to Deadly Drug Interactions, 1995, p. 133.
3 Pronsky, Z Food Medication Interactions, 11th edition, 1999
4 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.
4 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
4 Facts and Comparisons, Review of Natural Products, Clinisphere 2.0, Wolters Kluwer Company, 2000
5 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.
5 Facts and Comparisons, Review of Natural Products, Clinisphere 2.0, Wolters Kluwer Company, 2000
6 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
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The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.