Data provided by Applied Health
side effects, nutrient depletions, herbal interactions and health notes:
• Vitamin E enhances insulin activity and should, therefore, be avoided while taking oral hypoglycemics such as Prandin, without consulting a physician.1
• Avoid or limit alcohol use with this medication.2
• Take 1/2 an hour prior to meals.3
• Coenzyme Q10 may potentiate the hypoglycemic effects of this drug.4
• Grapefruit juice may enhance the pharmocologic effects of this drug.5
• Diabetes may be affected by many nutritional deficiencies, and using diabetic medications may increase the body’s nutritional needs. Ask your physician about supplementing the diet with a multivitamin.6
• Other nutrients that could be affected with use of this drug include coenzyme Q10. Discuss supplementation with a pharmacist or physician before initiating supplement use because Co-Q10 may also reduce blood sugar levels. Monitor sugar levels.7
• High doses of the vitamin niacin may increase blood glucose levels. Excessive use of this nutrient should be avoided.8
• Alcohol use should be limited since it can interfere with diabetes management.9
• Avoid magnesium and vitamin E supplements together with this medication due to possible increased drug effects.10
• Avoid L-carnitine and chromium with this drug because it could have additive blood sugar lowering effects.11
• Potatoes can interfere with blood sugar levels and the medication dosage may require adjustment.12
• It may be advisable to avoid glucosamine in diabetes. It may raise insulin resistance.13
• The following herbs may potentiate the hypoglycemic effects of this drug: Aloes, Bilberry, Blueberry, Burdock, Celery, Cornsilk, Fenugreek, Garlic, Ginger, Juniper, and Nettle.14
• The following herbs may lower blood sugar levels: Alfalfa, Aloe vera, Bilberry leaf, Burdock, Bitter Melon, Celery, Cornsilk, Damiana, Eucalyptus, Fenugreek, Garlic, Ginger, Panax Ginseng, Goat's Rue, Juniper, Marshmallow, Myrrh, Nettle, Onions, Sage and Tansy.15
• Due to the known interactions between salicylates and this medication, avoid the following herbs that have salicylate properties: meadowsweet, poplar and white willow.16
References1 Paolisso G, D'Amore A, Giugliano D, et al. Pharmacologic doses of vitamin E improve insulin action in healthy subjects and non-insulin-dependent diabetic patients. Am J Clin Nutr 57:650-656, 1993.
1 Paolisso G, D'Amore A, Galzerano D, et al. Daily vitamin E supplements improve metabolic control but not insulin secretion in elderly type II diabetic patients. Diabetes Care 16: 1433-1437, 1993.
2 Pronsky, Z Food Medication Interaction, 11th edition, 1999
3 Pronsky, Z Food Medication Interaction, 11th edition, 1999
3 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
4 Singh RB, Niaz MA, Rastogi SS, et al. Effect of hydrosoluble coenzyme Q10 on blood pressures and insulin resistance in hypertensive patients with coronary artery disease. J Human Hypertens 13: 203-208, 1999.
4 Kishi T, Kishi H, Watanabe T, et al: Bioenergetics in clinical medicine - studies on coenzyme Q and diabetes mellitus, J Med, 1976, 7(3-4):307-21.
5 Ho PC, Saville DJ, Coville PF, Wanwimolruk S. Content of CYP3A4 inhibitors, naringin, naringenin and bergapten in grapefruit and grapefruit juice products. Pharm Acta Helv. 2000 Apr;74(4):379-85.
6 "The Medical Letter on Drugs and Therapeutics," (New Rochelle, NY, The Medical Letter, Inc.) thru Vol. 37 (952), July, 1995.
6 Berger W, Incidence of severe side effects during therapy with sulfonylureas and biguanides, Horm Metab Res Suppl, 1985, 15:111-5.
6 Rieder HP, Berger W, and Fridrich R: Vitamin status in diabetic neuropathy, Z Ernahrungswiss, 1980, 19 (1):1-13.
6 Carpentier JL, Bury J, Luyckx A, et al: Vitamin B12 and folic acid serum levels in diabetics under various therapeutic regimens, Diabete Metab, 1976, 2(4):187-90.
7 Kishi T, Kishi H, Watanabe T, et al: Bioenergetics in clinical medicine - studies on coenzyme Q and diabetes mellitus, J Med, 1976, 7(3-4):307-21.
7 Singh RB, Niaz MA, Rastogi SS, et al. Effect of hydrosoluble coenzyme Q10 on blood pressures and insulin resistance in hypertensive patients with coronary artery disease. J Human Hypertens 13: 203-208, 1999.
8 Balch JF, Balch PA: Prescription for Nutritional Healing, 1997, p. 231.
8 Schwartz ML. Severe reversible hyperglycemia as a consequence of niacin therapy. Arch Intern Med. 1993 Sep 13;153(17):2050-2.
8 Pronsky, Z Food Medication Interactions, 11th edition, 1999
9 Graedon J, Graedon T: The People’s Guide to Deadly Drug Interactions, 1995, p. 284.
9 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
9 Pronsky, Z Food Medication Interactions, 11th edition, 1999
10 Paolisso G, D'Amore A, Giugliano D, et al. Pharmacologic doses of vitamin E improve insulin action in healthy subjects and non-insulin-dependent diabetic patients. Am J Clin Nutr 57:650-656, 1993.
10 Kivisto KT, Neuvonen PJ. Enhancement of absorption and effect of glipizide by magnesium hydroxide. Clin Pharmacol Ther 1991;49:39-43.
10 Tutuncu NB, Bayraktar M, Varli K. Reversal of defective nerve conduction with vitamin E supplementation in type 2 diabetes: a preliminary study. Diabetes Care. 1998 Nov;21(11):1915-8.
10 McBain AM, Brown IR, Menzies DG, Campbell IW. Effects of improved glycaemic control on calcium and magnesium homeostasis in type II diabetes. J Clin Pathol 1988;41:933-35.
11 Mingrone G. L-carnitine improves glucose disposal in type 2 diabetic patients. J Am Col Nutr 18: 77-82, 1999.
11 Anderson RA. Nutritional factors influencing the glucose/insulin system: chromium. J Am Coll Nutr. 1997 Oct;16(5):404-10.
12 Gannon MC, et al. Diabetes Care 1993;16:874.
13 Miles PD, Higo K, Olefsky JM. Exercise-stimulated glucose turnover in the rat is impaired by glucosamine infusion. Diabetes. 2001 Jan;50(1):139-42.
13 Ross SA, Chen X, Hope HR, Sun S, McMahon EG, Broschat K, Gulve EA. Development and comparison of two 3T3-L1 adipocyte models of insulin resistance: increased glucose flux vs glucosamine treatment. Biochem Biophys Res Commun. 2000 Jul 14;273(3):1033-41.
13 Monauni T, Zenti MG, Cretti A, Daniels MC, Targher G, Caruso B, Caputo M, McClain D, Del Prato S, Giaccari A, Muggeo M, Bonora E, Bonadonna RC. Effects of glucosamine infusion on insulin secretion and insulin action in humans. Diabetes. 2000 Jun;49(6):926-35.
13 The Review of Natural Products, Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
14 Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
14 Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
14 Facts and Comparisons, Review of Natural Products, Clinisphere 2.0, Wolters Kluwer Company, 2000
15 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.
15 Bever BO and Zahnd GR. Plants with oral hypoglycemic action. Q J Crude Drug Res 17: 139-196, 1979.
15 Welihinda J, et al. Effect of Momordica charantia on the glucose tolerance in maturity onset diabetes. J Ethnopharmacol 17: 277-282, 1986.
15 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
15 Yongchaiyudha S, Rungpitarangsi V, Bunyapraphatsara N, et al. Antidiabetic activity of Aloe vera L. juice. I. Clinical trial in new cases of diabetes mellitus. Phytomedicine. 1996;3:241-243.
15 Neef H, et al. Inhibitory effects of Galega officinalis on glucose transport across monolayers of human intestinal epithelial cells (Caco-2). Pharm Pharmacol Lett 1996;6(2):86-89.
16 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
16 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.
16 The Review of Natural Products, Clinisphere 2.0, Wolters Kluwer Company, 2000
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The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.