Data provided by Applied Health
side effects, nutrient depletions, herbal interactions and health notes:
• Taking Phenergan may create an increased requirement for riboflavin (Vitamin B-2) .1
• The use of alcohol should be avoided when taking Phenergan.2
• Co-Q-10 may be depleted with long term use of the medication.3
• Vitamin E supplementation may help prevent tardive dyskinesia, a side effect associated with long term use of phenothiazines. Supplementation should not be undertaken without the knowledge/ supervision of a physician or pharmacist.4
• Phenylalanine may make tardive dyskinesia worse when taken with phenothiazines.5
• Phenergan may hinder certain actions of the herb Shizandra.6
• Milk thistle may protect the liver against toxicity associated with long term phenothiazine use.7
• Ginkgo may help decrease side effects and increase effectiveness of some antipsychotic medications.8
• Yohimbe toxicity may increase with concurrent phenothiazine use.9
• These herbs may increase the risk of sedation with phenergan: calamus, calendula, chamomile, California poppy, catnip, couch grass, elecampane, ginseng Siberian, goldenseal, gotu kola, hops, Jamaican dogwood, kava, lemon balm, sage, St. John's wort, sassafras, scullcap, shepherd's purse, stinging nettle, valerian, withania root, and yerba mansa.10
References1 Pinto, J. T. & Rivlin, R. S.: Drugs that promote renal excretion of riboflavin. Drug Nutrient Interactions, 1987, 5: 143-151.
1 Tinguely D, Jonzier M, Schopf J, et al. Determination of Compliance with Riboflavin in an Antidepressive Therapy. Arzneimittelforschung, 1985, 35(2): 536-8
1 Pronsky, Z Food Medication Interactions, 11th edition, 1999
2 Mindell, E, Hopkins V: Prescription Alternatives. New Canaan, CT: Keats Publishing, Inc, 1998; p. 255.
2 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
2 Pronsky, Z Food Medication Interactions, 11th edition, 1999
3 Folkers K. Basic chemical research on coenzyme Q10 and integrated clinical research on therapy of diseases. As cited in Lenaz G (ed.). Coenzyme Q. New York: John Wiley and Sons, 1985.
3 Kishi T, et al, "Inhibition of Myocardial Respiration by Psychotherapeutic Drugs an Prevention by Coenzyme Q" Biomedical and Clinical Aspects of Coenzyme Q, Yamamura Y, Folkers K and Ito Y, eds Elsevier/North-Holland Biomedical Press: Amsterdam, 1980, vol 2, 139-54.
4 Adler LA, et al. Long term treatment effects of vitamin E for tardive dyskinesia. Biol Psychiatry 43: 868-872, 1998.
4 Elkashef AM, Wyatt RJ. Tardive dyskinesia: possible involvement of free radicals and treatment with vitamin E. Schizophr Bull. 1999;25(4):731-40. Review.
5 Mosnik DM, Spring B, Rogers K, and Baruah SL. Tardive dyskinesia exacerbated after ingestion of phenylalanine by schizophrenic patients. Neuropsychopharmacology 16(2): 136-146, 1997
5 Gardos G, Cole JO, Matthews JD, Nierenberg AA, Dugan SJ. The acute effects of a loading dose of phenylalanine in unipolar depressed patients with and without tardive dyskinesia. Neuropsychopharmacology. 1992 Jun;6(4):241-7.
6 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996:21,45,63,282.
7 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
7 Palasciano G, et al. The effect of silymarin on plasma levels of malondialdehyde in patients receiving long term treatment with psychotropic drugs. Curr Ther Res 55: 537-545, 1994.
8 Liu P, et al. Combined use of Ginkgo biloba extracts on efficacy and adverse reactions of various antipsychotics. Zhongguo Linchuang Yaolixue Zaxhi 13(4): 193-198, 1997.
9 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
10 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.
10 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
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The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.