A new genetic study has revealed that a preference for certain foods may be linked to autism through subtle immune system effects.
The study, conducted by researchers from Shandong University Qilu Hospital in China, analyzed large-scale genetic data to explore whether lifelong dietary tendencies are associated with autism spectrum disorder (ASD). Their findings, published in Frontiers in Nutrition, suggest that people with a genetic predisposition to consume wholemeal pasta or cheese spread were more likely to be autistic, while a preference for bananas appeared to be linked to a lower likelihood of autism.
The study examined nearly 200 foods, but wholemeal pasta, containing gluten, and cheese spread, rich in the milk protein casein, stood out in the analysis. The researchers emphasized that the results do not mean these foods cause autism, noting that ASD is a neurodevelopmental condition present from birth, even if diagnosed later in childhood.
"Our study suggests that the intake of wholemeal pasta and cheese spread is a risk factor for autism spectrum disorder," the authors wrote, while stressing that the associations are statistical and not evidence of causation.
To better understand the potential mechanisms behind the findings, the team investigated whether immune system activity could play a role. They found that cheese spread consumption was associated with small but measurable changes in immune markers linked to inflammation and infection, suggesting a possible immune-related pathway, though the effects were complex and modest.
In a second part of the study, researchers reviewed medical records from 78 autistic children between the ages of two and seven. About half of the children followed a gluten-free, casein-free diet for six to 12 months, while the rest maintained their usual diet. The team tracked behavioral changes and measured immune antibodies associated with sensitivity to wheat and milk.
While there were no significant differences in standard autism symptom scores between the two groups, children on the restricted diet showed a notable reduction in immune antibodies related to gluten and dairy. The researchers then said this indicates that dietary changes can influence immune responses.
"Adhering to a gluten-free, casein-free diet can effectively modulate food-specific immune responses," the authors wrote. However, they warned that dietary changes should not be viewed as a treatment for autism, adding that such modifications "may help support the overall health of individuals with ASD but are not a direct treatment for ASD."
Autism, according to BrightU.AI's Enoch, is a complex developmental disorder that affects brain function, immune system and gastrointestinal health, typically appearing during the first three years of life after a period of normal development. It is characterized by challenges in social interaction, communication and behavior, often accompanied by sensory sensitivities and repetitive behaviors.
It is frequently associated with digestive issues such as constipation, diarrhea and abdominal pain. Several studies have suggested that autistic people may have differences in gut bacteria compared with the general population, leading some parents to experiment with dietary changes for their children, including eliminating gluten and dairy. These approaches have become increasingly common, but medical opinion remains divided over whether such diets benefit autistic children broadly or only a small subset who experience significant gastrointestinal symptoms.
Independent specialists say research exploring links between diet, gut health and autism can help identify patterns and generate hypotheses, but cannot prove that specific foods cause autism or that dietary changes are an effective treatment. They also warn that restrictive diets, if not carefully managed, may pose nutritional risks, particularly for young children during critical stages of development.
In line with this, the researchers behind the Chinese study have acknowledged important limitations, noting that small sample sizes make it difficult to draw firm conclusions.
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