Chemotherapy linked to mitochondrial dysfunction in skeletal muscle
01/21/2019 // Ralph Flores // Views

A study published in the American Journal of Physiology-Cell Physiology has found that chemotherapy can cause adverse effects on the skeletal muscle of patients undergoing treatment. In the study, researchers from the University of Vermont looked at whether chemotherapeutics for breast cancer impact skeletal muscle structure and protein expression.

  • The researchers involved 13 women diagnosed with breast cancer and undergoing chemotherapy as part of their initial treatment after tumor resection. In addition, 12 healthy women took part as nondiseased controls.
  • An examination of those with breast cancer revealed reduced single-muscle fiber cross-sectional area and fractional content of subsarcolemmal and intermyofibrillar mitochondria.
  • The patients who had received chemotherapeutic drugs, in particular, doxorubicin and paclitaxel exhibited reductions in myosin expression, mitochondrial loss, and increased reactive oxygen species (ROS) production in C2C12 murine myotube cell cultures. This supported initial findings on the role of chemotherapy in atrophic and mitochondrial phenotypes.
  • After the patients were treated with mitochondrial-targeted antioxidant MitoQ, researchers noted a drop in chemotherapy-induced myosin depletion, mitochondrial loss, and ROS production.
  • Patients who underwent chemotherapy also exhibited increased levels of peroxiredoxin 3, a mitochondrial peroxidase linked to reductions in muscle fibers.

Researchers concluded that chemotherapy can negatively affect skeletal muscle in patients undergoing therapy.

Learn more about the negative effects of chemotherapy at

Journal Reference:

Guigni BA, Callahan DM, Tourville TW, Miller MS, Fiske B, Voigt T, Korwin-Mihavics B, Anathy V, Dittus K, Toth MJ. Skeletal muscle atrophy and dysfunction in breast cancer patients: role for chemotherapy-derived oxidant stress. American Journal of Physiology-Cell Physiology. November 2018;315(5). DOI: 10.1152/ajpcell.00002.2018

Take Action:
Support Natural News by linking to this article from your website.
Permalink to this article:
Embed article link:
Reprinting this article:
Non-commercial use is permitted with credit to (including a clickable link).
Please contact us for more information.
Free Email Alerts
Get independent news alerts on natural cures, food lab tests, cannabis medicine, science, robotics, drones, privacy and more.
App Store
Android App
eTrust Pro Certified

This site is part of the Natural News Network © 2022 All Rights Reserved. Privacy | Terms All content posted on this site is commentary or opinion and is protected under Free Speech. Truth Publishing International, LTD. is not responsible for content written by contributing authors. The information on this site is provided for educational and entertainment purposes only. It is not intended as a substitute for professional advice of any kind. Truth Publishing assumes no responsibility for the use or misuse of this material. Your use of this website indicates your agreement to these terms and those published here. All trademarks, registered trademarks and servicemarks mentioned on this site are the property of their respective owners.

This site uses cookies
Natural News uses cookies to improve your experience on our site. By using this site, you agree to our privacy policy.
Learn More
Get 100% real, uncensored news delivered straight to your inbox
You can unsubscribe at any time. Your email privacy is completely protected.