Home
Subscribe (free)
About NaturalNews
Contact Us
Write for NaturalNews
Media Info
Advertising Info

Supplementing with vitamin B3 precursor helps prevent hearing loss


Vitamin B3

Most Viewed Articles
https://www.naturalnews.com/047973_vitamin_B3_nicotinamide_riboside_hearing_loss.html
Delicious
diaspora
Print
Email
Share

(NaturalNews) A chemical precursor to vitamin B3 may help prevent the hearing loss caused by exposure to loud noises, according to a study conducted by researchers from Weill Cornell Medical College and the Gladstone Institutes and published in the journal Cell Metabolism.

"One of the major limitations in managing disorders of the inner ear, including hearing loss, is there are a very limited number of treatments options," said first author Kevin Brown, MD, PhD, who is now at the University of North Carolina. "This discovery identifies a unique pathway and a potential drug therapy to treat noise-induced hearing loss."

The vitamin B3 precursor, known as nicotinamide riboside (NR), increases the activity of a protein that not only protects against hearing loss but may also help prevent a wide variety of age-related disorders.

The study was funded by Weill Cornell, the Gladstone Institutes, the New York State Department of Health Spinal Cord Injury Fund and the National Institutes of Health.

Prevents hearing damage even after noise exposure

The body turns NR not just into vitamin B3 but also into another related compound, nicotinamide adenine dinucleotide (NAD+). In laboratory studies, Brown and co-senior author Samie Jaffrey found that NAD+ could prevent injury in the nerve cells of a part of the ear known as the cochlea. The cochlea is the part of the ear that transmits sound into the spiral ganglion, which then sends the information on to the brain. The hair cells and nerve synapses are particularly vulnerable to damage from loud noise.

NAD+ is a highly unstable compound, however, causing the researchers to worry that it would be ineffective in living animals. For that reason, they carried out an animal trial using NR instead. This was made possible by a recent advance by co-author Anthony Sauve, PhD, who developed a new method allowing NR to be synthesized in quantities high enough for animal studies.

"NR gets into cells very readily and can be absorbed when you take it orally," Jaffrey said. "It has all the properties that you would expect in a medicine that could be administered to people."

The researchers exposed mice to NR either before or after exposing them to noises loud enough to cause cochlear damage. They found that regardless of whether it was administered before or after the noise, NR reduced synaptic damage in mice. In addition, mice treated with NR suffered less hearing loss in both the short and the long term. Mice gained the same degree of protection regardless of when the NR was administered.

Same chemical may prevent diseases of aging

NR and NAD+ are both known to increase activity of a protein known as sirtuin 3 (SIRT3), which plays a key role in maintaining healthy functioning of mitochondria, which provide energy to cells. The researchers hypothesized that this effect might underlie the chemicals' protective benefits. In a followup experiment, they found that mice who had their SIRT3 levels artificially increased were just as resistant to noise damage to their cochlea as mice given NR. Similarly, mice who had their SIRT3 gene removed gained no benefit from NR.

Because levels of SIRT3 naturally decline with age, the researchers have suggested that lowered levels of this protein might be responsible for some of the effects of aging, and for the development of certain age-related diseases. SIRT3 levels also naturally vary fairly widely between individuals, which may also explain why some people tend to stay healthier as they age.

"The success of this study suggests that targeting SIRT3 using NR could be a viable target for treating all sorts of aging-related disorders--not only hearing loss but also metabolic syndromes like obesity, pulmonary hypertension, and even diabetes," co-senior author Eric Verdin, MD, said.

Sources:

http://gladstoneinstitutes.org

http://science.naturalnews.com

http://truthwiki.org/Vitamin_B3_-_Niacin

Join the Health Ranger's FREE email newsletter
Get breaking news alerts on GMOs, fluoride, superfoods, natural cures and more...
Your privacy is protected. Unsubscribe at any time. | Learn more...

comments powered by Disqus


Support NaturalNews Sponsors:

Support NaturalNews Sponsors:

Get alerted on heavy metals and pesticide test results for foods and supplements

Natural News is about to begin releasing lab test results for off-the-shelf food, supplement and pet food products, covering heavy metals, nutritive minerals, pesticides and herbicides. These details will be released exclusively to Natural News email newsletter subscribers (FREE) and will NOT be publicly posted on the website. To be alerted, join our free email newsletter now, and watch for lab test results in the weeks ahead.

Enter your email address below to subscribe to our email announcement list (but don't use gmail). Your privacy is protected and you can unsubscribe at any time. If you don't join our email list, you may never see our valuable content again via Facebook, Google or YouTube. CENSORSHIP has now reached EXTREME levels across the 'net. The truth is being suffocated. Subscribe now if you want to escape the delusional bubble of false reality being pushed by Google and Facebook.

Once you click subscribe, we will send you an email asking you to confirm your free subscription.