Data provided by Applied Health
side effects, nutrient depletions, herbal interactions and health notes:
• Cozaar may cause weight gain. A low calorie, low-sodium diet with an increased intake of fiber is recommended.1
• Cozaar may contribute to the depletion of CoQ10. Supplementation may be beneficial.2
• Potassium supplements and potassium constituents should be avoided while taking this drug.3
• Grapefruit juice may enhance the pharmocologic effects of this drug.4
• Natural licorice products, Ginseng, and Ephedra (Ma huang) may cause hypertension, and should therefore be avoided.5
• These herbs have cardioactive properties which may increase the side effects of cozaar if used together: black hellebore, calamus, cereus, cola, coltsfoot, devil's claw, European mistletoe, fenugreek, fumitory, digitalis leaf, hedge mustard, figwort, lily of the valley roots, motherwort, pleurisy root, squill bulb leaf scales, white horehound, mate, scotch broom flower, shepherd's purse, and wild carrot6
References1 Pronsky, ZM: Food-Medication Interactions, 11th edition, 1999
2 Kishi H, Kishi T, Folkers K: Bioenergetics in clinical medicine III - inhibition of coenzyme Q10-enzymes by clinically used antihypertensive drugs, Res Commun Chem Pharmacol, 1975, 12(3):533-40.
3 Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000.
4 Ho PC, Saville DJ, Coville PF, Wanwimolruk S. Content of CYP3A4 inhibitors, naringin, naringenin and bergapten in grapefruit and grapefruit juice products. Pharm Acta Helv. 2000 Apr;74(4):379-85.
4 Soldner A, Christians U, Susanto M, Wacher VJ, Silverman JA, Benet LZ. Grapefruit juice activates P-glycoprotein-mediated drug transport. Pharm Res. 1999 Apr;16(4):478-85.
4 Zaidenstein R, Avni B, Dishi V, et al. Effect of grapefruit juice on the pharmacokinetics of losartan in healthy volunteers. Clin Pharmacol Ther, 1998;65(2): (abstract PI-60).
5 Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
5 Blumenthal, et al. The Complete German Commission E Monographs, American Botanical Council, Integrative Medicine, 1998
6 Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.
6 PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
6 Facts and Comparisons, The Review of Natural Products, Clinisphere 2.0, Wolters Kluwer Company, 2000
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The information in Drug Watch is provided as a courtesy to NewsTarget readers by Applied Health Solutions in cooperation with Healthway Solutions. Although the information is presented with scientific references, we do not wish to imply that this represents a comprehensive list of considerations about any specific drug, herb or nutrient. Nor should this information be considered a substitute for the advice of your doctor, pharmacist, or other healthcare practitioner. Please read the disclaimer about the intentions and limitations of the information provided on these pages. It is important to tell your doctor and pharmacist about all other drugs and nutritional supplements that you are taking if they are recommending a new medication. Copyright © 2007 by Applied Health Solutions, Inc. All rights reserved.