Based on these results, the researchers concluded that IM38 attenuates colitis by inhibiting HFD-induced LPS production in gut microbiota through the regulation of Proteobacteria to Bacteroidetes ratio and NF-KB activation in the colon. They also believe that IM38 may be a suitable ingredient of functional foods designed to treat or prevent colitis.
Journal Reference:
Lim SM, Kim DH. BIFIDOBACTERIUM ADOLESCENTIS IM38 AMELIORATES HIGH-FAT DIET-INDUCED COLITIS IN MICE BY INHIBITING NF-KB ACTIVATION AND LIPOPOLYSACCHARIDE PRODUCTION BY GUT MICROBIOTA. Nutrition Research. 2017;41:86–96. DOI: 10.1016/j.nutres.2017.04.003