folate

Folate and vitamin B12 treat schizophrenia symptoms

Tuesday, March 12, 2013 by: Sherry Baker, Health Sciences Editor
Tags: vitamin B12, folate, schizophrenia

eTrust Pro Certified

Most Viewed Articles
Popular on Facebook
BACK INTO THE CLOSET: Why U.S. reporters are not allowed to write about rainbow events in nations where being gay is still condemned
Depopulation test run? 75% of children who received vaccines in Mexican town now dead or hospitalized
A family destroyed: Six-month-old dies after clinic injects baby with 13 vaccines at once without mother's informed consent
Biologist explains how marijuana causes tumor cells to commit suicide
U2's Bono partners with Monsanto to destroy African agriculture with GMOs
Companies begin planting microchips under employees' skin
BAM! Chipotle goes 100% non-GMO; flatly rejecting the biotech industry and its toxic food ingredients
ECONOMIC SLAVERY FOR ALL: While we were distracted with the Confederate flag flap, Congress quietly forfeited our entire economic future via fast-track trade authority
NJ cops bust teenagers shoveling snow without a permit
Russia throws down the gauntlet: energy supply to Europe cut off; petrodollar abandoned as currency war escalates
McDonald's in global profit free fall as people everywhere increasingly reject chemically-altered toxic fast food
Chemotherapy kills cancer patients faster than no treatment at all
March Against Monsanto explodes globally... World citizens stage massive protests across 38 countries, 428 cities... mainstream media pretends it never happened
600 strains of an aerosolized thought control vaccine already tested on humans; deployed via air, food and water
Italian court rules mercury and aluminum in vaccines cause autism: US media continues total blackout of medical truth
The 21 curious questions we're never allowed to ask about vaccines
Vicious attack on Dr. Oz actually waged by biotech mafia; plot to destroy Oz launched after episode on glyphosate toxicity went viral
Orthorexia Nervosa - New mental disorder aimed at people who insist on eating a clean diet

Delicious
(NaturalNews) Schizophrenia is a disabling brain disorder characterized by the inability to tell reality from imagination, according to the National Institutes of Health (NIH). Symptoms are broken down into two types called "positive symptoms," which include hallucinations and delusions, and "negative symptoms" which include social withdrawal, apathy, and a lack of emotional expressiveness. While drugs have been found to help many with the positive type of symptoms, too often there's no help for the negative variety - until now. A new study has found that taking dietary supplements folate and vitamin B12 can alleviate these symptoms in some patients.

In a new placebo-controlled study of 140 patients with schizophrenia, a research team based at Massachusetts General Hospital (MGH) found improvement across all participants when folate and B12 were added to their regular treatments. But the results were most significant in those carrying specific variants in genes involved with folate metabolism.

The report has just been published in JAMA Psychiatry (formerly Archives of General Psychiatry) online. It's the first study designed specifically to investigate whether supplementation with folate and B12 (which increases the effects of folate) can treat the symptoms of schizophrenia.

"The symptoms of schizophrenia are complex, and antipsychotic medications provide no relief for some of the most disabling parts of the illness. These include negative symptoms, which can be particularly devastating," Joshua Roffman, MD, MMSc, of the MGH Department of Psychiatry, corresponding author of the JAMA Psychiatry paper, said in a media statement.

"Our finding that folate plus vitamin B12 supplementation can improve negative symptoms opens a new potential avenue for treatment of schizophrenia. Because treatment effects differed based on which genetic variants were present in each participant, the results also support a personalized medical approach to treating schizophrenia."

So why would the essential nutrient folate (often found in supplements in the folic acid form) have a positive impact on the devastating condition known as schizophrenia? In their paper, the researchers note that folate is necessary for the synthesis of DNA and neurotransmitters and it plays a role in the control of gene expression. Previous studies have linked folate deficiency during pregnancy with an increased risk of schizophrenia among offspring. Earlier research by members of the MGH-based team found low blood folate levels were associated with the more severe, negative symptoms among patients with schizophrenia.

"Folate plays a critical role in DNA methylation, which regulates gene expression, so it's plausible that its effects on negative symptoms act through gene expression changes," Dr. Roffman, an assistant professor of psychiatry at Harvard Medical School, explained in a media statement. "Participants with the low-functioning FOLH1 variant (a gene involved in folate metabolism) might eventually show a benefit of folate supplementation if treated for a longer period of time, but that needs to be investigated in future studies."

"Understanding more about the basic neural mechanisms of folate in patients with schizophrenia could help us generate more targeted and effective interventions to reduce and possibly even prevent symptoms."

Sources:

http://www.massgeneral.org/about/pressrelease.aspx?id=1559
http://archpsyc.jamanetwork.com/article.aspx?articleid=1660588
http://www.naturalnews.com/folic_acid.html

About the author:
Sherry Baker is a widely published writer whose work has appeared in Newsweek, Health, the Atlanta Journal and Constitution, Yoga Journal, Optometry, Atlanta, Arthritis Today, Natural Healing Newsletter, OMNI, UCLA''''s "Healthy Years" newsletter, Mount Sinai School of Medicine''''s "Focus on Health Aging" newsletter, the Cleveland Clinic''''s "Men''''s Health Advisor" newsletter and many others.

Join over four million monthly readers. Your privacy is protected. Unsubscribe at any time.
comments powered by Disqus
Take Action: Support NaturalNews.com by linking back to this article from your website

Permalink to this article:

Embed article link: (copy HTML code below):

Reprinting this article:
Non-commercial use OK, cite NaturalNews.com with clickable link.

Follow Natural News on Facebook, Twitter, Google Plus, and Pinterest

Advertise with NaturalNews...

Support NaturalNews Sponsors:

Advertise with NaturalNews...

GET SHOW DETAILS
+ a FREE GIFT

Sign up for the FREE Natural News Email Newsletter

Receive breaking news on GMOs, vaccines, fluoride, radiation protection, natural cures, food safety alerts and interviews with the world's top experts on natural health and more.

Join over 7 million monthly readers of NaturalNews.com, the internet's No. 1 natural health news site. (Source: Alexa.com)

Your email address *

Please enter the code you see above*

No Thanks

Already have it and love it!

Natural News supports and helps fund these organizations:

* Required. Once you click submit, we will send you an email asking you to confirm your free registration. Your privacy is assured and your information is kept confidential. You may unsubscribe at anytime.