cancer

Breaking news: cancer drugs make tumors more aggressive and deadly

Thursday, January 19, 2012 by: S. L. Baker, features writer
Tags: cancer drugs, tumors, aggressive

eTrust Pro Certified

Delicious Pin It
(NaturalNews) When natural health advocates warn against mainstream medicine's arsenal of weapons used to fight cancer, including chemotherapy and radiation, their concerns often revolve around how these therapies can weaken and damage a person's body in numerous ways. But scientists are finding other reasons to question some of these therapies. It turns out that while chemotherapies may kill or shrink tumors in the short term, they may actually be causing malignancies to grow more deadly in the long term.

For example, NaturalNews previously reported (http://www.naturalnews.com/029042_cancer_cells_chemotherapy.html) that scientists at the University of Alabama at Birmingham (UAB) Comprehensive Cancer Center and UAB Department of Chemistry are currently investigating the very real possibility that dead cancer cells left over after chemotherapy spark cancer to spread to other parts of the body (metastasis). And now comes news that a little-explored specific cell type, the pericyte, found in what is called the microenvironment of a cancerous tumor actually may halt cancer progression and metastasis. And by destroying these cells, some anti-cancer therapies may inadvertently be making cancer more aggressive as well as likely to spread and kill.

A study just published in the January 17 issue of the journal Cancer Cell concludes that anti-angiogenic therapies (which shrink cancer by cutting off tumors' blood supply) may be killing the body's natural defense against cancer by destroying pericyte cells that likely serve as important gatekeepers against cancer progression and metastasis. Pericytes cover blood vessels and support their growth.

For the new research, Raghu Kalluri, MD, PhD, Chief of the Division of Matrix Biology at Beth Israel Deaconess Medical Center (BIDMC) and Professor of Medicine at Harvard Medical School (HMS), investigated whether targeting pericytes could inhibit tumor growth in the same way that other antiangiogenic cancer drugs do.

Dr. Kalluri and his research team worked with mice genetically engineered to support drug-induced depletion of pericytes in growing tumors. Next, they removed pericytes in implanted mouse breast cancer tumors, decreasing pericyte numbers by 60 percent.

Compared with control animals, there was a 30 percent decrease in the size of cancerous tumors over 25 days. But there was a serious catch to these results. Contrary to conventional mainsteam medical wisdom, the scientists discovered the number of secondary lung tumors in the engineered mice had increased threefold compared to the control mice, indicating that the tumors had metastasized.

How cancer drugs can spread cancer cells

"If you just looked at tumor growth, the results were good," Dr. Kalluri said in a press statement. "But when you looked at the whole picture, inhibiting tumor vessels was not controlling cancer progression. The cancer was, in fact, spreading. This suggested to us that without supportive pericytes, the vasculature inside the tumor was becoming weak and leaky -- even more so than it already is inside most tumors-- and this was reducing the flow of oxygen to the tumor."

That change, he explains, makes cancer cells more mobile, so they can travel through those leaky vessels to new locations. It also makes cancer cells behave more like stem cells, so they are better able to survive.

Because cancer therapies such as Imatinib, Sunitinib and others are known to decrease pericytes in tumors, the scientists next carried out the same experiments in mice with primary tumors. Only this time, they used the chemotherapy drugs Imatinib and Sunitinib instead of genetic programs to decrease pericyte numbers. Both Imatinib and Sunitinib caused 70 percent pericyte depletion -- and they also increased metastasis threefold.

In order to see if their findings are relevant to human patients, the research team examined 130 breast cancer tumor samples of varying cancer stages and tumor sizes and compared pericyte levels with prognoses. The result? The samples with low numbers of pericytes in tumor vasculature correlated with the most deeply invasive cancers, distant metastasis and five to ten year survival rates less than 20 percent.

"These results are quite provocative and will influence clinical programs designed to target tumor angiogenesis," Ronald A. DePinho, president of the University of Texas MD Anderson Cancer Center, said in a press statement. "These impressive studies will inform and refine potential therapeutic approaches for many cancers."

For more information:

http://www.bidmc.org/

Get breaking news alerts on GMOs, fluoride, superfoods, natural cures and more...
Join over four million monthly readers. Email privacy 100% protected. Unsubscribe at any time.


Have comments on this article? Post them here:

comments powered by Disqus

Take Action: Support NaturalNews.com

Email this article to a friend

Permalink to this article:

Reprinting this article: Non-commercial use OK, cite NaturalNews.com with clickable link.

Embed article link: (copy HTML code below):
Most Popular
Today | Week | Month | Year

See all Top Headlines...



GET SHOW DETAILS
+ a FREE GIFT

Now Available at ShopNaturalNews.com

O3 Essentials OraJuvenate™
A powerful, cleansing dental cream for maximum oral/dental health.
New Cancer Solutions
Over 3 hours of content covering today’s best cancer tests, how to kill cancer cells and the best diets and exercise routines.
Freeze-Dried 100% Organic Whole Corn
Our freeze-drying method preserves taste, texture and nutrients better than any other food preservation method ever invented.
Fenix TK35 Flashlight
Tough, waterproof, extremely bright and it’s touted to throw an 800+ lumen beam more than 1,000 feet into the night.
Inca Treasure Smoothie Pack
This pack of our four most popular superfoods from South America is the perfect combo pack for smoothie lovers.
Pink Himalayan Salt
This salt delivers significant levels of magnesium, zinc and selenium, with trace levels of dozens of other elements.
Pinhole Glasses - Aviator Style
Pinhole glasses are becoming famous for helping people improve their vision without the risks of laser surgery.
Oxy-Rich Facial Serum
O3 Essentials Jojoba Oxy-Rich Facial Serum is cellular nourishment for your skin. Helps smooth fine lines while enhancing tissue elasticity.
Freeze-Dried 100% Blackberry Halves
Our freeze-dried blackberry halves are grown in Serbia under strict organic standards.

Also on NaturalNews:

Health Ranger Videos
Activist music
CounterThink Cartoons
Food documentaries
FREE Special Reports
Podcasts
Colloidal Silver

Advertise with NaturalNews...

Support NaturalNews Sponsors:

Advertise with NaturalNews...

Most Popular Stories

Flu shot kills 19-year-old, but vaccine industry still has total immunity against lawsuits
Here's a nutty fact: Eating more tree nuts lowers the risk of all-cause death by up to 20 percent
Six important facts you're not being told about lost Malaysia Airlines Flight 370
Malaysia Airlines Flight 370 now clearly a government cover-up: All evidence contradicts official story
10 other companies that use the same Subway yoga mat chemical in their buns
BLM fracking racket exposed! Armed siege and cattle theft from Bundy ranch really about fracking leases
High-dose vitamin C injections shown to annihilate cancer
U.S. treating meat with ammonia, bleach and antibiotics to kill the '24-hour sickness'
USDA to allow U.S. to be overrun with contaminated chicken from China
Vaccine fraud exposed: Measles and mumps making a huge comeback because vaccines are designed to fail, say Merck virologists
Battle for humanity nearly lost: global food supply deliberately engineered to end life, not nourish it
Diet soda, aspartame linked to premature deaths in women

25 Amazing Facts About Food

This FREE downloadable report unveils a collection of astonishing and little-known facts about the food we eat very day. Click here to read it now...

 

Resveratrol and its Effects on Human Health and Longevity - Myth or Miracle.

Unlock the secrets of cellular health with the "miracle" nutrient Resveratrol Click here to read it now...

 

Nutrition Can Save America

FREE online report shows how we can save America through a nutrition health care revolution. "Eating healthy is patriotic!" Click here to read it now...

The Healing Power of Sunlight and Vitamin D

In this exclusive interview, Dr. Michael Holick reveals fascinating facts on how vitamin D is created and used in the human body to ward off chronic diseases like cancer, osteoporosis, mental disorders and more. Click here to read it now...

Vaccines: Get the Full Story

The International Medical Council on Vaccination has released, exclusively through NaturalNews.com, a groundbreaking document containing the signatures of physicians, brain surgeons and professors, all of which have signed on to a document stating that vaccines pose a significant risk of harm to the health of children. Click here to read it now...

Health Ranger Storable Organics

GMO-free, chemical-free foods and superfoods for long-term storage and preparedness. See selection at www.StorableOrganics.com



Recommended Resources On:

Natural News trends
Health Ranger news
Natural News GMOs
Mike Adams tracker
Natural News photos
Natural News Global
Natural News in focus
Natural News connect
Natural News shocking stories
Natural News radar
GMOs
Quackwatch
Vaccines
Health freedom
Dr. Paul Offit

This site is part of the Natural News Network © 2014 All Rights Reserved. Privacy | Terms All content posted on this site is commentary or opinion and is protected under Free Speech. Truth Publishing International, LTD. is not responsible for content written by contributing authors. The information on this site is provided for educational and entertainment purposes only. It is not intended as a substitute for professional advice of any kind. Truth Publishing assumes no responsibility for the use or misuse of this material. Your use of this website indicates your agreement to these terms and those published here. All trademarks, registered trademarks and servicemarks mentioned on this site are the property of their respective owners.

eTrust Pro Certified Android app on Google Play

Sign up for the FREE Natural News Email Newsletter

Receive breaking news on GMOs, vaccines, fluoride, radiation protection, natural cures, food safety alerts and interviews with the world's top experts on natural health and more.

Join over 7 million monthly readers of NaturalNews.com, the internet's No. 1 natural health news site. (Source: Alexa.com)

Your email address *

Please enter the code you see above*

No Thanks

Already have it and love it!

Natural News supports and helps fund these organizations:

* Required. Once you click submit, we will send you an email asking you to confirm your free registration. Your privacy is assured and your information is kept confidential. You may unsubscribe at anytime.