Summary

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http://www.bloomberg.com/apps/news?pid=10000085&sid=a264d5EE3xNE&refer=europe

Details

• Alzheimer's disease researchers at Rhode Island Hospital and Brown Medical School said they found more evidence that the condition may be a new type of diabetes, or insulin deficiency, specific to the brain.
• The researchers discovered a ``significant'' drop in levels of insulin and insulin receptors in the brains of patients who had early stage Alzheimer's and died, according to a study released today.
• The scientists reported earlier this year that they'd found lower levels in patients with advanced Alzheimer's.
• Without insulin, the brain is unable to make acetylcholine, a chemical that carries signals among neurons and helps in the thinking process, according to researcher Suzanne de la Monte, a neuropathologist at Rhode Island Hospital.
• ``If you don't have the insulin, or the brain cells don't respond'' to it, the cells will die, de la Monte said in a Nov. 28 telephone interview.
• The research suggests that one way to slow the onset of Alzheimer's might be a treatment that improves the brain cells' use of insulin, de la Monte said.
• Before the findings can be applied, scientists must first determine a way to identify insulin deficiency or insulin resistance in the brains of living patients, she said.
• For this study, which is being published in the November issue of the Journal of Alzheimer's Disease, the researchers drew on a brain bank for a postmortem study of the brains of about 50 Alzheimer's patients.
• Conventional diabetes is diagnosed by measuring blood glucose levels, blood insulin levels and how the body manages high levels of sugar, said de la Monte, who is also a pathology professor at Brown Medical School in Providence, Rhode Island.
• Different organs can react in varying ways to insulin.
• Most patients with Alzheimer's don't have diabetes, and there is no evidence that diabetes patients have a higher risk for Alzheimer's, de la Monte said.

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