Summary
Fatty acids can have a protective effect against the peptides associated with the degeneration of the brain and Alzheimer's disease, according to Louisiana State University researchers, reports Science Daily.
Original source:
http://www.sciencedaily.com/releases/2005/09/050911105120.htm
Details
- The authors report that DHA can decrease levels of the pathogenic Abeta peptides that are associated with Alzheimer disease pathology in human brain cells.
- Meanwhile, the synthesis of neuroprotectin D1 (NPD1), an endogenous DHA-derived messenger, is upregulated.
- NPD1 inhibits apoptosis triggered by Abeta peptides.
- In a human AD donor brain, the authors show that DHA and NPD1 are reduced in vulnerable brain regions.
- This data raises the possibility that NPD1 is a key regulator of cell survival, and might be manipulated for the development of novel therapeutic strategies for neurodegenerative diseases.
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