Does stress have benefits? A certain form of stress may be linked to longer life, say scientists
03/26/2020 // Darnel Fernandez // Views

Stress is the body's natural reaction to various life experiences, and everyone is bound to experience it at one point in their lives. High levels of stress can bring about negative effects on the body. However, recent research describes a new type of stress that can bring surprising benefits for health.

Anything from day-to-day responsibilities, like work and school, to serious life events, like getting a new diagnosis on some form of disease, can trigger stress. Symptoms of chronic stress range from headaches to an increased risk of getting a viral infection. If left untreated, stress can also worsen the symptoms of other chronic diseases like diabetes and heart disease.

Now, a study published in the journal Science Advances found a novel form of stress called chromatin architectural defect or chromatin stress that actually promotes longevity. The study findings suggest that this stress response may pave the way for brand new ways to intervene in human aging and increase the chances of living a longer life.

"Chromatin stress refers to disruptions in the way DNA is packed within the nucleus of the cell," said corresponding author Weiwei Dang. "One of the factors that influences chromatin structure is proteins called histones."

A good type of stress

According to researchers from the Baylor College of Medicine and the Houston Methodist Research Institute, histone proteins wrap around the DNA found in the nuclei of cells, creating a "beads-on-a-string" structure they describe as chromatin. Other types of proteins bind along the structure, causing it to fold into more complicated configurations. When chromatin stress happens, any form of disruption on the structure can create unwanted changes in the gene expression of these proteins. (Related: Scientists develop home-testing kit that measures stress hormones.)

Brighteon.TV

Using samples of the yeast Saccharomyces cerevisiae, the researchers aimed to determine how the dosage of histone genes would affect longevity. The analysis was done under the assumption that the yeast samples that carry fewer copies of histones than normal, or the control yeast, would have shorter lives. Instead, the researchers discovered that the latter lived much longer than any of the controls.

The researchers attributed this increased longevity to a reduction of histone gene expression and an increase in chromatin stress. The samples' response to chromatin disruption was marked by changes in the activation of a number of genes that promoted longevity.

In a previous research, Dang and his colleagues determined that chromatin structure progressively falls apart in aging cells. Alterations in histone genes, like a decrease in protein, are primary indicators of the aging process. However, the researchers noted that they could compensate for the decrease in histone levels by over-expressing some histone genes.

"We have identified a previously unrecognized and unexpected form of stress that triggers a response that benefits the organism," said first author Ruofan Yu. "The mechanism underlying the chromatin stress response generated by moderate reduction of histone dosage is different from the one triggered by histone overexpression we had previously described, as shown by their different profiles of protein expression responses."

In addition, the researchers discovered that the chromatin stress in the yeast samples also occurred in other organisms like roundworms (Caenorhabditis elegans), fruit flies and mouse embryonic stem cells. However, only yeast and C. elegans exhibited extended longevity as a response to chromatin stress.

All in all, the researchers concluded that chromatin stress induced by chromatin defection promotes longevity in certain organisms. The findings suggest that this particular stress response may be present in other organisms as well.

Learn more about the varying effects of stress on the body at MindBodyScience.news.

Sources include:

ScienceDaily.com

OnlineMasters.Ohio.edu

Advances.ScienceMag.org



Take Action:
Support Natural News by linking to this article from your website.
Permalink to this article:
Copy
Embed article link:
Copy
Reprinting this article:
Non-commercial use is permitted with credit to NaturalNews.com (including a clickable link).
Please contact us for more information.
Free Email Alerts
Get independent news alerts on natural cures, food lab tests, cannabis medicine, science, robotics, drones, privacy and more.
App Store
Android App
eTrust Pro Certified

This site is part of the Natural News Network © 2022 All Rights Reserved. Privacy | Terms All content posted on this site is commentary or opinion and is protected under Free Speech. Truth Publishing International, LTD. is not responsible for content written by contributing authors. The information on this site is provided for educational and entertainment purposes only. It is not intended as a substitute for professional advice of any kind. Truth Publishing assumes no responsibility for the use or misuse of this material. Your use of this website indicates your agreement to these terms and those published here. All trademarks, registered trademarks and servicemarks mentioned on this site are the property of their respective owners.

This site uses cookies
Natural News uses cookies to improve your experience on our site. By using this site, you agree to our privacy policy.
Learn More
Close
Get 100% real, uncensored news delivered straight to your inbox
You can unsubscribe at any time. Your email privacy is completely protected.